Improving Plantarflexor Muscle Function to Alleviate Decline in Mobility, Loss of Balance and Detrimental Knee Joint Loading in Older Adults
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 2
- 主要终点
- Change from baseline in knee joint loading
研究概览
简要总结
This study investigates the role of calf muscle function in gait performance, balance and knee joint loading.
Previous studies have linked age-related loss of calf muscle function with impairments in gait performance and balance, and increased loading of the areas of the knee joint that are susceptible to the development of osteoarthritis. In this study, an exercise intervention targeting structural and neural aspects of impaired calf muscle function with ageing is utilized. The intervention lasts 8 weeks and includes either biofeedback training using electromyography to alter muscle activation patterns or a combination of biofeedback training and strength training for the calf muscle to modify calf function during walking. The study will test whether the intervention improves walking speed, reduces the metabolic cost of walking, improves standing balance and reduces knee joint loading.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 65 Years 至 75 Years（Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •age between 65 and 75
排除标准
- •dependent living status
- •not able to walk without an assistive device or for 30 min without stopping
- •diagnosed neurological disease or joint disorder and pain during walking
- •surgery on lower extremities
- •current musculoskeletal injury
- •previous cardiovascular event or symptoms during exercise (acute ECG change, coronary disease, symptomatic arrhythmia, symptomatic coronary stenosis, heart failure, myocarditis, pericarditis, pulmonary embolism, pulmonary infarct, artery bulge or rupture risk)
- •body mass index <18 or >35 kg/m2
- •contraindications for magnetic resonance imaging
- •Mini Mental State Examination score of 23 points and lower
研究组 & 干预措施
Gait retraining
8-week intervention. Intervention includes weekly gait retraining sessions with real-time electromyography biofeedback.
干预措施: Gait retraining (Other)
Gait retraining + strength training
8-week intervention. Intervention includes weekly gait retraining sessions with real-time electromyography biofeedback and home-based strength training session for plantarflexor muscles three times per week.
干预措施: Gait retraining + strength training (Other)
结局指标
主要结局
Change from baseline in knee joint loading
时间窗: within 1 weeks after intervention
Change in tibiofemoral compressive loading during walking estimated using musculoskeletal modeling and simulation. Loading is calculated separately for medial and lateral compartments of the tibiofemoral joint.
次要结局
- Change from baseline in muscle strength(within 1 weeks after intervention)
- Change from baseline in joint moments during walking(within 1 weeks after intervention)
- Change from baseline in walking speed(within 1 weeks after intervention)
- Change from baseline in joint powers during walking(within 1 weeks after intervention)
- Change from baseline in distribution of joint work during walking(within 1 weeks after intervention)
- Change from baseline in energy cost of walking(within 1 weeks after intervention)
- Change from baseline in Achilles tendon stiffness(within 1 weeks after intervention)
- Change from baseline in standing balance(within 1 weeks after intervention)
- Change from baseline in muscle-tendon function during walking(within 1 weeks after intervention)
- Change from baseline in soleus to gastrocnemius muscle activation ratio(within 1 weeks after intervention)
- Change from baseline in gait kinematics(within 1 weeks after intervention)
研究者
Lauri Stenroth
Senior Researcher
University of Eastern Finland