Validation of 2 methods of continuous cardiac output measurement during exercise in patients with chronic heart failure: LiDCO and Physioflow

Completed

• Conditions: chronic heart failure; left ventricular dysfunction; 10019280

• Registration Number: NL-OMON30666
• Lead Sponsor: Máxima Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 18 June 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 10

Inclusion Criteria

Stable chronic heart failure due to myocardial infarction or dilating cardiomyopathy NYHA II-III
left ventricular ejection fraction < 40%

Exclusion Criteria

Factors that potentially influence the accuracy of the measurements:
- Lithium use
- Weight < 40 kg
- Atrial fibrillation / flutter
- Aortic aneurysm, aortic regurgitation
- Orthopaedic, pulmonary, neuromuscular or other conditions that influence the ability to exercise
- Chronic obstructive pulmonary disease (COPD) with FEV1/FVC < 60%
Factors that potentially increase the risk:
- Pregnancy
- Change of NYHA stage or medication in the last 2 months
- Myocardial infarction < 3 months before inclusion
- Unstable angina at rest with STT changes
- Severe aortic stenosis, hypertrophic obstructive cardiomyopathy, myocarditis
- Hypertension at rest (systolic >200 mmHg , diastolic > 100 mmHg)
- Prosthetic valve
- Atrial or ventricular thrombus
- Thrombo-embolic events in the past
- Positive Allen*s test

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Difference and agreement between lithium dilution and direct Fickk method at<br /><br>rest.<br /><br>Difference and agreement between PulseCO, Physioflow and the direct Fick<br /><br>method.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>not applicable</p><br>