Variability biomarkers of individual responses of the Cariorespiratory Fitness to aerobic training

Not Applicable

• Conditions: Sedentary Lifestyle; F01.829.458.705

• Registration Number: RBR-3rh38g
• Lead Sponsor: Faculdade de Educação Física da Universidade Estadual de Campinas

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2018-06-05
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Recruitment completed
• Sex: Male
• Target Recruitment: Not specified

Inclusion Criteria

Young sedentary healthy men; age between 18-30 years old

Exclusion Criteria

Smokers; hypertensive with systolic blood pressure higher than 140 and diastolic blood pressure higher than 90 mm Hg; diabetic with fasting glucose higher than 7.0 mmol L-1; severe obese defined defined as body mass index higher than 33 kg m-2; dyslipidemic based on medication; com evidence of heart diseases; metabolic disorders; significant chronic respiratory conditions or musculoskeletal problems interfering with exercise

Study & Design

• Study Type: Intervention
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Main outcome is the change in the cardiorespiratory fitness in response to training, which will be measured by the maximal oxygen uptake (ml/min) and maximal power output (W) performed during incremental test until exhaustion, pre and post 8-weeks training program

Secondary Outcome Measures

Name	Time	Method
Serum and skekeletal metabolite levels (mmol) analyzed by metabolomics . These metabolites will be used to the understanding of mechanisms associated to variation on main outcome (cardiorespiratory fitness) in response to training programs;Changes on body composition, measured by na composição corporal, mensurada by plethysmograph for analysis of fat-free mass and fat mass in kilograms (kg) and percentages (%) pre and post 8-weeks training program;Changes in lipid profile (total cholesterol, triglycerides, HDL, LDL, VLDL em mg/dL) pre and post 8-weeks training program;Changes in cardiac autonomic modulation measured by the heart rate variability using heart rate monitor (POLAR). Analysis will be performed on time domain (iRR, RMSSD e SDNN, in ms, and pNN50 em %) and frequency domain (LF, HF, VLF, LF/HF, TP, em ms2 e n.u.) pre and post 8-weeks training program