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临床试验/NCT07068282
NCT07068282已完成1 期

Vitamin D3, Mouthwash, Saliva Testing, Covid-19, Antiviral Testing

King Faisal Specialist Hospital & Research Center1 个研究点 分布在 1 个国家目标入组 25 人开始时间: 2024年7月24日最近更新:
干预措施
相关药物

试验速览

阶段
1 期
状态
已完成
入组人数
25
试验地点
1
主要终点
No effect of D3 mouthwash on saliva of COVID-19 patients

研究概览

简要总结

The PI's goal of this [interventional/clinical trial] is to [explore the antiviral properties of vitamin D3 on saliva samples collected before and after the use of a vitamin D3 mouthwash] in [ adult participants, both genders, with COVID-19 who tested positive on a swab test]. The main question[s] aims to answer [is]:

[Assess the antiviral potential of a novel vitamin D-based mouthwash in COVID-19-positive participants].

PI will compare both [Control group: saliva only- before use of mouthwash], and the [study group: after use of the mouthwash in saliva] to see if there is [any veridical effect present in saliva after running lab tests].

Participants will [self-collect saliva in a given tube (color coded orange), then 10-15 minutes later or more, participants will swish with D3 mouthwash, and will give another sample [saliva + mouthwash] in another (green labeled tube). For each participant, each of the following will be given:

  • 2 collecting tubes: orange labeled tube (for saliva collection only) and green labeled tube (for saliva collection after mouthwash use).
  • The vial containing vitamin D3 mouthwash.

详细描述

Twenty-five adult participants confirmed COVID-19-positive, via rapid antigen testing (RAT) thru nasal swabs (NS), followed by saliva samples collected before and after using a vitamin D3 mouthwash. Samples were analyzed using RAT and rapid polymerase chain reaction (R-PCR) to measure viral load.

研究设计

研究类型
Interventional
分配方式
Na
干预模型
Single Group
主要目的
Treatment
盲法
None

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • 未提供

排除标准

  • 未提供

研究组 & 干预措施

D3 mouthwash in COVID-19 saliva

Experimental

干预措施: Cholecalciferol (vitaminD3) (Drug)

结局指标

主要结局

No effect of D3 mouthwash on saliva of COVID-19 patients

时间窗: 30-60 minutes was the time frame for each participant, during same day of COVID-19 testing.

Post-rinse, RAT positivity dropped by 68%, likely due to physical dilution rather than antiviral action. R-PCR showed no significant reduction in viral RNA; in some cases, a slight increase was observed, potentially reflecting a cellular response to D3

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Sarah Feteih

Consultant, Periodontist

King Faisal Specialist Hospital & Research Center

研究点 (1)

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