Vitamin D3, Mouthwash, Saliva Testing, Covid-19, Antiviral Testing
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 25
- 试验地点
- 1
- 主要终点
- No effect of D3 mouthwash on saliva of COVID-19 patients
研究概览
简要总结
The PI's goal of this [interventional/clinical trial] is to [explore the antiviral properties of vitamin D3 on saliva samples collected before and after the use of a vitamin D3 mouthwash] in [ adult participants, both genders, with COVID-19 who tested positive on a swab test]. The main question[s] aims to answer [is]:
[Assess the antiviral potential of a novel vitamin D-based mouthwash in COVID-19-positive participants].
PI will compare both [Control group: saliva only- before use of mouthwash], and the [study group: after use of the mouthwash in saliva] to see if there is [any veridical effect present in saliva after running lab tests].
Participants will [self-collect saliva in a given tube (color coded orange), then 10-15 minutes later or more, participants will swish with D3 mouthwash, and will give another sample [saliva + mouthwash] in another (green labeled tube). For each participant, each of the following will be given:
- 2 collecting tubes: orange labeled tube (for saliva collection only) and green labeled tube (for saliva collection after mouthwash use).
- The vial containing vitamin D3 mouthwash.
详细描述
Twenty-five adult participants confirmed COVID-19-positive, via rapid antigen testing (RAT) thru nasal swabs (NS), followed by saliva samples collected before and after using a vitamin D3 mouthwash. Samples were analyzed using RAT and rapid polymerase chain reaction (R-PCR) to measure viral load.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
研究组 & 干预措施
D3 mouthwash in COVID-19 saliva
干预措施: Cholecalciferol (vitaminD3) (Drug)
结局指标
主要结局
No effect of D3 mouthwash on saliva of COVID-19 patients
时间窗: 30-60 minutes was the time frame for each participant, during same day of COVID-19 testing.
Post-rinse, RAT positivity dropped by 68%, likely due to physical dilution rather than antiviral action. R-PCR showed no significant reduction in viral RNA; in some cases, a slight increase was observed, potentially reflecting a cellular response to D3
次要结局
未报告次要终点
研究者
Sarah Feteih
Consultant, Periodontist
King Faisal Specialist Hospital & Research Center
