Comparison lactate clearance between high dose and conventional dose of Meropenem in sepsis patients Emergency Department; Post-HOC analysis of a randomized controlled trial

Phase 3

Completed

• Conditions: lactate clearancesepsis; sepsis; high dose meropenam; conventional dose meropenam; emergency department

• Registration Number: TCTR20200311001
• Lead Sponsor: Ramathibodi hospital Mahidol university

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2018-08-31
• Study Start: 2020-03-11
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 43

Inclusion Criteria

1) patients aged ≥ 18 years
2) patients who diagnosed as sepsis and septic shock according to sepsis-3 criteria
3) patients were receiving Meropenem as empirical eligible for enrollment

Exclusion Criteria

1) patients receiving Meropenem within 7 day before enrollment, 2) patients requiring operations within 72 hours after enrollment 3) patients having known allergy or had contraindication to Meropenem 4) patients who receiving Extracorporeal membrane oxygenation 5) patients who having sepsis with central nervous system infection, infective endocarditis or osteomyelitis, 6) patients with active seizure or status epilepticus 7) patients who receiving cardiopulmonary resuscitation before enrollment

Study & Design

• Study Type: Interventional
• Study Design: Not specified