Shortened Antibiotic Treatment in Community-Acquired Pneumonia: A Nationwide Danish Randomized Controlled Trial - CAP5

Thomas Benfield0 个研究点目标入组 336 人开始时间: 2019年3月14日最近更新: 2024年6月10日

适应症

试验速览

暂无简介。

•o Hospitalized with community-acquired pneumonia; defined as new pulmonary infiltrate on chest X-ray and at least one symptom compatible with pneumonia (cough, fever, dyspnoea and/or chest pain)
•o Initiation of antibiotics within 12 hours of the time of the chest X-ray with an infiltrate
•o Age = 18 years
•o Afebrile (temp = 37,8°C) for 48 hours at randomization
•o Clinically stable at randomization (SBP = 90 mm Hg, HR = 100/min., RR = 24/min., SAT = 90%)
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range 168
•F.1.3 Elderly (>=65 years) yes
•F.1.3.1 Number of subjects for this age range 168

•a) Immunosuppression (HIV-positive, neutropenia (<1 x 10^9/L), corticosteroid treatment (= 10 mg/d of prednisone or the equivalent for >30 days), chemotherapy within the past 90 days, untreated terminal cancer, immunosuppressive agents, immunosuppressed after solid organ transplantation, asplenia)
•b) Hospitalization during the previous 14 days
•c) Antibiotic treatment (>2 days) within the past 30 days, directed at lower respiratory tract pathogens
•d) Uncommon cause requiring longer duration of antimicrobial therapy (Pseudomonas aeruginosa, Staphylococcus aureus, Mycobacterium spp., fungi)
•e) Extrapulmonary infection (e.g. endocarditis, meningitis, or abscess)
•f) Pleural empyema or lung abscess
•g) Pleural effusion requiring drainage tube
•h) Intensive care unit (ICU) admittance
•i) Pregnancy and breastfeeding

发起方

Thomas Benfield