Shortened Antibiotic Treatment in Community-Acquired Pneumonia: A Nationwide Danish Randomized Controlled Trial - CAP5

Thomas Benfield0 个研究点目标入组 336 人2019年3月14日

概览

暂无简介。

注册库

who.int

开始日期

2019年3月14日

结束日期

待定

最后更新

去年

研究类型

Interventional clinical trial of medicinal product

性别

All

发起方

Thomas Benfield

•o Hospitalized with community\-acquired pneumonia; defined as new pulmonary infiltrate on chest X\-ray and at least one symptom compatible with pneumonia (cough, fever, dyspnoea and/or chest pain)
•o Initiation of antibiotics within 12 hours of the time of the chest X\-ray with an infiltrate
•o Age \= 18 years
•o Afebrile (temp \= 37,8°C) for 48 hours at randomization
•o Clinically stable at randomization (SBP \= 90 mm Hg, HR \= 100/min., RR \= 24/min., SAT \= 90%)
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1\.2 Adults (18\-64 years) yes
•F.1\.2\.1 Number of subjects for this age range 168
•F.1\.3 Elderly (\>\=65 years) yes

•a) Immunosuppression (HIV\-positive, neutropenia (\<1 x 10^9/L), corticosteroid treatment (\= 10 mg/d of prednisone or the equivalent for \>30 days), chemotherapy within the past 90 days, untreated terminal cancer, immunosuppressive agents, immunosuppressed after solid organ transplantation, asplenia)
•b) Hospitalization during the previous 14 days
•c) Antibiotic treatment (\>2 days) within the past 30 days, directed at lower respiratory tract pathogens
•d) Uncommon cause requiring longer duration of antimicrobial therapy (Pseudomonas aeruginosa, Staphylococcus aureus, Mycobacterium spp., fungi)
•e) Extrapulmonary infection (e.g. endocarditis, meningitis, or abscess)
•f) Pleural empyema or lung abscess
•g) Pleural effusion requiring drainage tube
•h) Intensive care unit (ICU) admittance
•i) Pregnancy and breastfeeding