A Clinical Study of Vyoshadya Saktu and Tryushanadi Guggulu in Medodushti wsr to Dyslipidemia

Phase 1/2

Not yet recruiting

• Conditions: Other heart disorders in diseasesclassified elsewhere. Ayurveda Condition: MEDOVAHASROTODUSHTIH,

• Registration Number: CTRI/2023/02/050007
• Lead Sponsor: Department of Kayachikitsa Shree Narayan Prasad Awasthi Govt Ayurved College Raipur CHHATTISGARH

Brief Summary

Medodushtidoes not bear a direct reference as a disease entity in Brihattrayi, though itcan be studied under the broad umbrella of Sthaulya or Medoroga, as a causativefactor, aetiopathogenesis, signs and symptoms, treatment is similar forMedoroga and Medodushti.According to modern opinion, the amount of totalcholesterol, triglyceride, LDL, VLDL, and HDL is abnormal in Dyslipidemiadisorder. This is due to the abnormal metabolism of lipids and lipoproteins.Due to this, there is a possibility of various complex diseases like coronaryheart disease (angina, ischemic heart disease, myocardial infarction) diabetes,cerebral-vascular disease, Hypertension, and atherosclerosis.In the presentera, Diseases caused by improper lifestyles are more challenging. Medodushti(Dyslipidemia) is exclusively one of the lifestyle disorders because Excessivestress, lack of exercise, day sleep, junk food, canned food, soft drinks, highfatty diet, and continuous intake of high-calorie food items lead to medodushti(Dyslipidemia) and coronary artery diseases.Dyslipidemia is anestablished and modifiable risk factor for coronary artery disease.Drugs usedin modern science to treat Dyslipidemia have several adverse effects likemyopathy, the potential increase in serum transaminase levels leading to liverdamage, nausea, bowel upset, etc.

Moreever, drugs like statins, fibrates, resins, etc. are expensive and thereforehard for common men to purchase.So, it needs time to find out a safe andcost-effective treatment for Dyslipidemia from Ayurveda.

 Most cases of dyslipidemia are due to the modernlifestyle full of sedentary lifestyles and unhealthy food habits.CardiovascularDiseases (CVD) have a high disease burden in India. Dyslipidemia, a major CVDrisk factor, requires effective management. Our review describes the efficacyof Vyoshadyasaktu and tryushanadi guggulu in the management of medodhusti (Dyslipidemia). Theprevalence of Dyslipidemia ranges from 25-30% in urban people and 15-20% inrural.It will be a single-center, nonrandomized, open‑clinical study. In this study,60 clinically diagnosed patients of medhodhusti (Dyslipidemia) will beselected. Vyoshadya saktu will be given in doses of 50 gm saktu + 3-gramaushadhi churna three times a day with lukewarm water before a meal along withtryushanadi Guggulu in the form of vati 500mg each 2 vati four times a day for90 days.  Statistical analysis will bedone using Wilcoxon signed rank test will be using for the analysis ofnonparametric data, while paired t-tests will be used for parametric dataanalysis.

Detailed Description

Not available

Study Timeline

• Study Start: 2023-01-03
• Last Update Posted: 2023-02-22

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• Age 25 years to 70 years patient.
• following range value was taken for the diagnosis of Dyslipidemia.
• Cholesterol > 200 mg/dl or/and 2.
• Triglycerides > 150 mg/dl or/and 3.
• S.L.D.L >130 mg/dl or/and 4.
• S.L.D.L >30 mg/dl or/and 5.
• S.H.D.L < 40 mg/dl.

Exclusion Criteria

• 1.Age below 25 years and above 70 years.
• 2.Liver cirrhosis 3.Liver failure 4.Chronic renal failure 5.Patients suffering from D.M. that were poorly controlled and uncontrolled hypertension.
• 6.Nephrotic syndrome 7.Tuberculosis 8.Ascites 9.Cancer.
• 10.Patients having H/o – Serious cardiac disorder like MI, Cardiac failure.
• 11.Pregnant female and lactating mothers.
• 12.Known cases of Immunocompromised state (AIDS).

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Normalized the value of lipid profile in dyslipidemia (medodushti in ayurveda)	8 weeks

Secondary Outcome Measures

Name	Time	Method
improve the quality of life	90 days

Trial Locations

Locations (1)

Shri Narayan Prasad Awasthi Govt. Ayurved College Raipur CHHATTISGARH; 🇮🇳 Raipur, CHHATTISGARH, India

Shri Narayan Prasad Awasthi Govt. Ayurved College Raipur CHHATTISGARH

🇮🇳Raipur, CHHATTISGARH, India

DrBhanu Pratap Patel

Principal investigator

7987824964

bhanupatel128@gmail.com