ACTRN12612000625875
已完成
3 期
Randomised double blinded placebo controlled trial to assess the effect of oral nicotinamide on numbers of new nonmelanoma skin cancers in immune competent adult patients with a history of at least two histologically confirmed nonmelanoma skin cancers within the previous five years
概览
- 阶段
- 3 期
- 干预措施
- 未指定
- 疾病 / 适应症
- 未指定
- 发起方
- niversity of Sydney
- 入组人数
- 386
- 状态
- 已完成
- 最后更新
- 6年前
概览
简要总结
暂无简介。
研究者
入排标准
入选标准
- •Aged 18 years or older with at least two histologically confirmed nonmelanoma skin cancers with the previous 5 years
- •Equivalent to Year 8 spoken and written English skills to participate in the cognitive component of the study.
排除标准
- •1\.Immune suppression (due to current immune suppressive medication, or immune suppressive medical condition such as haematological malignancy, HIV infection, congenital immune deficiency)
- •2\.Severe liver disease (transaminases \>3x normal)
- •3\.Active peptic ulcer disease
- •4\.Recent myocardial infarction
- •5\.Hypotension
- •6\.Renal impairment with eGFR \< 30 mL/min/1\.73 m2
- •7\.Internal malignancy, metastatic SCC or invasive melanoma within the past 5 years.
- •8\.Need for ongoing carbamazepine use (possible interaction with nicotinamide).
- •9\.Patients unavailable for follow up for the duration of the study because of general frailty, geographical or social reasons.
- •10\.Gorlin’s syndrome or other genetic skin cancer syndrome.
结局指标
主要结局
未指定
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