Effects of neuromuscular blockade on transpulmonary pressure and diaphragm activity in paediatric moderate-to-severe acute respiratory distress syndrome: a pilot study - PedNMB.2

niversitair Medisch Centrum Groningen0 个研究点目标入组 19 人开始时间: 待定最近更新: 2024年6月11日

适应症

试验速览

暂无简介。

•Informed consent
•Age younger than 12 years
•Need for mechanical ventilation with tidal volume 5 - 8 mL/kg ideal bodyweight and a mimum PEEP level of 5 cmH2O
•Early moderate - to - severe paediatric acute respiratory distress syndrome originating from any cause:
•Acute onset of disease, and
•Oxygenation index > 12, and
•One or more (bilateral) infiltrates on chest radiograph, and
•No evidence of left ventricular failure or fluid overload, and
•Within the first 48 hours of diagnosis of PARDS
•Indication for continuous infusion of NMBAs at discretion of the attending physician

•No informed consent
•Continuous administration of neuromuscular blockade prior at the time of meeting the criteria for PARDS
•Chronic respiratory failure on home ventilation
•Intracranial hypertension
•Bone marrow transplantation
•Immunocompromised patients (congenital or acquired)
•Pre-existing pulmonary hypertension
•Congenital heart disease with left - to - right shunting
•Cyanotic congenital heart disease
•Withdrawal of life - sustaining treatment
•Prematurity (gestational age less than 44 weeks when assessed for eligibility)
•History of congenital neuromuscular disorder

发起方