NL-OMON45389
Completed
Not Applicable
Effects of neuromuscular blockade on transpulmonary pressure and diaphragm activity in paediatric moderate-to-severe acute respiratory distress syndrome: a pilot study - PedNMB.2
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- PARDS
- Sponsor
- niversitair Medisch Centrum Groningen
- Enrollment
- 19
- Status
- Completed
- Last Updated
- last year
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Informed consent
- •Age younger than 12 years
- •Need for mechanical ventilation with tidal volume 5 \- 8 mL/kg ideal bodyweight and a mimum PEEP level of 5 cmH2O
- •Early moderate \- to \- severe paediatric acute respiratory distress syndrome originating from any cause:
- •Acute onset of disease, and
- •Oxygenation index \> 12, and
- •One or more (bilateral) infiltrates on chest radiograph, and
- •No evidence of left ventricular failure or fluid overload, and
- •Within the first 48 hours of diagnosis of PARDS
- •Indication for continuous infusion of NMBAs at discretion of the attending physician
Exclusion Criteria
- •No informed consent
- •Continuous administration of neuromuscular blockade prior at the time of meeting the criteria for PARDS
- •Chronic respiratory failure on home ventilation
- •Intracranial hypertension
- •Bone marrow transplantation
- •Immunocompromised patients (congenital or acquired)
- •Pre\-existing pulmonary hypertension
- •Congenital heart disease with left \- to \- right shunting
- •Cyanotic congenital heart disease
- •Withdrawal of life \- sustaining treatment
Outcomes
Primary Outcomes
Not specified
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