Optimising salbutamol dose for wheezy preschool childre

Not Applicable

Completed

• Conditions: Respiratory; Disease: All Diseases; Topic: Children; Subtopic: All Diagnoses

• Registration Number: ISRCTN15513131
• Lead Sponsor: Brighton and Sussex University Hospitals NHS Trust

Brief Summary

2016 Protocol article in https://www.ncbi.nlm.nih.gov/pubmed/27836009 protocol

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2015-04-08
• Study Completion: 2019-06-30
• Last Update Posted: 13 September 2021

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 84

Inclusion Criteria

1. Age 2 years 6 months to 6 years 11 months
2. Recurrent wheeze, defined as at least 3 episodes of wheeze over the previous 12 months by the parent

Exclusion Criteria

1. Other major airway or lung disease, e.g. chronic lung disease of prematurity, cystic fibrosis, and abnormal airway anatomy
2. Recent (within 2 weeks) treatment with systemic corticosteroids or leukotriene inhibitors
3. Participants involved in other research currently or recently

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Bronchodilator response to salbutamol using lung function test (interrupter resistance Rint) at baseline and 30 minutes after each dose of salbutamol.