Finger capillary refilling time variations to evaluate effects of fluid administration in critically ill patients
Not Applicable
- Conditions
- Hypovolemia (loss of blood volume) in critically ill patientsNutritional, Metabolic, EndocrineVolume depletion
- Registration Number
- ISRCTN58464956
- Lead Sponsor
- Centre Hospitalier Universitaire Brugmann
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Ongoing
- Sex
- All
- Target Recruitment
- 100
Inclusion Criteria
1. Central venous line present in internal jugular vein and arterial line
2. PvaCO2 >6mmHg
Exclusion Criteria
1. Age <18 years
2. Extracorporeal membrane oxygenation (ECMO) support
3. Interventions within 15 minutes before FB: increase inotrope dosage, introduction of mechanical ventilation
4. Arterial or venous PCO2 >75mmHg before or after FB
5. FB for acute bleeding
6. Admission to ICU or hemodynamic instability for less than 6 hours
7. Interventions (i.e. changes in ventilator parameters, change in the dose of inotropes) within 1h before FB
8. Severe peripheric vasoconstriction or hypothermia: not possible to evaluate peripheral saturation with pulse oximetry
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <br> Measured before, during, and after intake of the fluid bolus:<br> 1. Capillary refilling time measured using a chronometer<br> 2. PvaCO2 measured using blood gas analysis with using blood gas analysis devices (RAPID Point 500®; Siemens Health-care Limited, Germany)<br>
- Secondary Outcome Measures
Name Time Method <br> Measured before, during, and after intake of the fluid bolus:<br> 1. Cardiac index measured with transthoracic echocardiography<br> 2. Mean arterial pressure measured using sphygmomanometer<br>