Nor-epinephrine Versus Midodrine/Octreotide in Patients With Hepatorenal Acute Kidney Injury
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 91
- 试验地点
- 1
- 主要终点
- Full response
研究概览
简要总结
Hepatorenal syndrome is a functional renal impairment occurring in cirrhotic patients . It develops secondary to splanchnic arterial vasodilatation which decreases the effective blood volume, activate the renin-angiotensin-aldosterone system, and stimulate of sympathetic nervous system.This study aims to compare the efficacy of nor-epinephrine versus midodrine/ octreotide, together with intravenous albumin on renal functions of patients with hepatorenal acute kidney injury.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Both sexes aged 18 years or older having cirrhosis, ascites, and a diagnosis of HRS-AKI based on the 2015 International Club of Ascites (ICA) diagnostic criteria
排除标准
- •Serum creatinine (sCr) >7 mg/dL Hypotension (mean arterial pressure (MAP) <70 mm Hg) or sepsis. Recent treatment with vasopressors. Patients with severe cardiovascular disease Known allergy to study medications
研究组 & 干预措施
Midodrine/Octreotide
oral midodrine plus octreotide as subcutaneous injection
干预措施: Midodrine/Octreotide (Drug)
Nor-epinephrine
Intravenous infusion norepinephrine
干预措施: Nor-epinephrine (Drug)
结局指标
主要结局
Full response
时间窗: 10 days
the proportion of patients achieved full response defined as return of serum creatinine to a value within 0.3 mg/dl of the baseline value
次要结局
- Partial response(10 days)
- Reversal(10 days)
研究者
Doaa abdelaziz
Lecturer of clinical pharmacy
National Hepatology & Tropical Medicine Research Institute