The Effect of Metformin on the Correlation Between Hyperinsulinemia and Hypertension

Not Applicable

Completed

• Conditions: Diabetes Mellitus; Essential Hypertension
• Interventions: Drug: Fosinopril; Drug: Metformin

• Registration Number: NCT01342614
• Lead Sponsor: China-Japan Friendship Hospital

Brief Summary

The objective of this study is to investigate the effect of metformin on the correlation between hyperinsulinemia and hypertension.

Detailed Description

Not available

Study Timeline

• Status Verified: 2005-11
• Study Start: 2006-05
• Primary Completion: 2009-08
• Study Completion: 2009-08
• Study First Submitted: 2011-04-26
• Study First Submitted QC: 2011-04-26
• Study First Posted: 2011-04-27
• Last Update Submitted: 2011-05-11
• Last Update Posted: 2011-05-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 140

Inclusion Criteria

• 20 to 65 years of age, regardless of sex
• duration of hypertension was <5 years
• overweight or obesity, mild to moderate hypertension, receive no euglycemic agent or antiobesity drug

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Fosinopril group	Fosinopril	Fosinopril group received fosinopril, 10mg, once per day.
Metformin group	Metformin	Metformin group was treated with metformin hydrochloride, 500mg, three times per day

Primary Outcome Measures

Name	Time	Method
Blood pressure measurement	8 weeks