Study on Prognosis of Acute-on-chronic Liver Failure Complicated by Bacterial or Fungal Infection
- Conditions
- Acute-On-Chronic Liver Failure
- Registration Number
- NCT06437067
- Lead Sponsor
- Qin Ning
- Brief Summary
The subjects of this study were inpatients with ACLF who were admitted to Tongji Hospital in Wuhan from March 2023 to June 2025. After patients were enrolled, The patient's general information (gender, age, past medical history, etc.), complications (ascites, hepatic encephalopathy, hepatorenal syndrome, gastrointestinal bleeding, etc.), laboratory tests (CRP, PCT, INR, WBC, fungal/bacterial diagnostic tests, etc.), symptoms and signs at the time of infection, and at admission (D1), D4, D7, D14, D21, etc.) were recorded Save the blood separately. The patients were divided into fungal infection group, bacterial infection group and non-infection group according to the infection status after admission.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 400
- TBIL ≥ 12 mg/mL and INR ≥ 1.5
- Chronic hepatitis B
(1) <18 or >80 years old; (2) primary hepatic or extrahepatic carcinoma; (3) with severe diseases of other organs or systems; (4) pregnancy; (5) imcomplete information
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method mortality rate of bacterial or fungal infection 28 days and 90 days mortality rate of bacterial or fungal infection
incidence rate of bacterial or fungal infection 28 days and 90 days incidence rate of bacterial or fungal infection
- Secondary Outcome Measures
Name Time Method incidence rate of complications 28 days and 90 days incidence rate of complications
Trial Locations
- Locations (1)
Department of Infectious Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
🇨🇳Wuhan, Hubei, China