Patient-ventilator Asychrony During Non-invasive Ventilation When COPD Patients Doing Exercise
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- COP
- Sponsor
- Guangzhou Medical University
- Enrollment
- 10
- Locations
- 1
- Primary Endpoint
- Asynchrony index
- Last Updated
- 5 years ago
Overview
Brief Summary
Pulmonary rehabilitation programmes including aerobic exercise training have strong evidence of effectiveness in improving exercise capacity, dyspnoea and HRQL in patients with COPD. Therefore, current guidelines recommend pulmonary rehabilitation, including exercise training, in these patients. Non-invasive ventilation(NIV) is increasingly used during exercise training programmes in order to train patients at intensity levels higher than allowed by their clinical and pathophysiological conditions. Patient-ventilator asynchrony (PVA) describes the poor interaction between the patient and the ventilator and is the consequence of the respiratory muscle activity of the patient being opposed to the action of the ventilator.PVA have unfavourable clinical impace on gas exchange, dyspnoea perception, patient comfort and tolerance and reduced adherence to NIV. This study is going to detect whether the PVA will increase when COPD patients exercise with NIV supporingt
Investigators
Zhenfeng He
Principle investigator
Guangzhou Medical University
Eligibility Criteria
Inclusion Criteria
- •Age 40-80, males and females;
- •Stage III and IV COPD;
- •Similar with non-invasive ventilation;
- •Willing to participate in the study;
- •Able to provide informed consent.
Exclusion Criteria
- •Presented with an acute exacerbation during previous 3 months;
- •Bronchiectasis; post-tuberculosis sequelae; rib cage deformities; neuromuscular disorders; and bronchial carcinoma.
- •Intolerant with NIV
Outcomes
Primary Outcomes
Asynchrony index
Time Frame: 5 hours
Asynchrony index is defined as the number of asynchrony events divided by the total respiratory rate computed as the sum of the number of ventilator cycles (triggered or not) and of wasted efforts: asynchrony Index (expressed in percentage) = number of asynchrony events/total respiratory rate (ventilator cycles +wasted efforts) × 100
Secondary Outcomes
- Partial pressure of arterial blood carbon dioxide (PaCO2)(5 hours)
- COPD assessment test(5 hours)
- 6-minute walk test(5 hours)
- Severe Respiratory Insufficiency (SRI) Questionnaire(5 hours)