Patient-ventilator Asychrony During Non-invasive Ventilation When COPD Patients Doing Exercise
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 10
- 试验地点
- 1
- 主要终点
- Asynchrony index
研究概览
简要总结
Pulmonary rehabilitation programmes including aerobic exercise training have strong evidence of effectiveness in improving exercise capacity, dyspnoea and HRQL in patients with COPD. Therefore, current guidelines recommend pulmonary rehabilitation, including exercise training, in these patients. Non-invasive ventilation(NIV) is increasingly used during exercise training programmes in order to train patients at intensity levels higher than allowed by their clinical and pathophysiological conditions. Patient-ventilator asynchrony (PVA) describes the poor interaction between the patient and the ventilator and is the consequence of the respiratory muscle activity of the patient being opposed to the action of the ventilator.PVA have unfavourable clinical impace on gas exchange, dyspnoea perception, patient comfort and tolerance and reduced adherence to NIV. This study is going to detect whether the PVA will increase when COPD patients exercise with NIV supporingt
研究设计
- 研究类型
- Observational
- 观察模型
- Case Crossover
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 40 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age 40-80, males and females;
- •Stage III and IV COPD;
- •Similar with non-invasive ventilation;
- •Willing to participate in the study;
- •Able to provide informed consent.
排除标准
- •Presented with an acute exacerbation during previous 3 months;
- •Bronchiectasis; post-tuberculosis sequelae; rib cage deformities; neuromuscular disorders; and bronchial carcinoma.
- •Intolerant with NIV
结局指标
主要结局
Asynchrony index
时间窗: 5 hours
Asynchrony index is defined as the number of asynchrony events divided by the total respiratory rate computed as the sum of the number of ventilator cycles (triggered or not) and of wasted efforts: asynchrony Index (expressed in percentage) = number of asynchrony events/total respiratory rate (ventilator cycles +wasted efforts) × 100
次要结局
- Partial pressure of arterial blood carbon dioxide (PaCO2)(5 hours)
- COPD assessment test(5 hours)
- 6-minute walk test(5 hours)
- Severe Respiratory Insufficiency (SRI) Questionnaire(5 hours)
研究者
Zhenfeng He
Principle investigator
Guangzhou Medical University