A Cluster-randomized Controlled Trial of Promoting Antiretroviral Therapy Among Serodiscordant Couples to Reduce HIV Transmission
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 11,096
- 试验地点
- 5
- 主要终点
- HIV seroconversion rate of HIV negatives among HIV serodiscordant couples
研究概览
简要总结
The purpose of this study is to evaluate the effectiveness of reducing HIV transmission among sero-discordant couples by applying comprehensive intervention components.
详细描述
A cluster-randomized controlled trial was carried out in forty counties from 16 cities. The strategy of Social Marketing was applied to influence sero-discordant couples' behavioral changes including safer sexual intercourses, regular HIV testing for the negative partners, antiretroviral therapy initiation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 59 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Couples are required to have a stable relationship and live together in the last 3 months;
- •Older than 18 years and younger than 60 years; without regard to CD4 count;
- •Open cohort(any newly diagnosed serodiscordant couples who are eligible for treatment will be included during the study period).
排除标准
- •Couples are not have a stable relationship or do not live together in the last 3 months;
- •Younger than 18 years old.
研究组 & 干预措施
Intervention
comprehensive intervention components
干预措施: comprehensive intervention components (Behavioral)
Usual
According the National HIV Antiretroviral treatment Guideline, provide treatment referrals for those treatment-eligible HIV-positive patients.
结局指标
主要结局
HIV seroconversion rate of HIV negatives among HIV serodiscordant couples
时间窗: up to 2 years
次要结局
- Proportion of HIV positives receiving ART among HIV serodiscordant couples(up to 2 years)
- The incidence rate of AIDS-related diseases of HIV positives among serodiscordant couples(up to 2 years)