First Repair Treatment with Transcatheter Closure followed by Pulmonary Vasodilator Therapy in Patients with Pulmonary Arterial Hypertension associated with Atrial Septal Defect
- Conditions
- pulmonary hypertension associated with atrial septal defect patients between 5 and 10 wood units of pulmonary vascular resistance
- Registration Number
- JPRN-UMIN000018877
- Lead Sponsor
- Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 0
Not provided
A.Co-exist of other cause PH (collagen, pulmonary diseases, pulmonary embolism, left heart disease) B.Co-exist of other congenital heart diseases except for ASD C.Treatment of PAH-specific drugs(prostacyclin, endothelin receptor antagonist, PDE5 inhibitor, soluble guanylate cyclase stimulator) D.Eisenmenger syndorome(Qp/Qs<1) E.Bleeding or risk of bleeding F.Atrial fibliration G.Pregnat or possible pregnant woman and lactating woman H.moderate renal dysfunction (Cre more than 1.5mg/dl) I.moderate liver dysfunction (AST and ALT more than 2 times normal limit) J.Hypotension (sBP less than 90mmHg) K.Low cardiac output (cardiac index under 2.2l/min/m2) L.LV ejection fraction under 50% M.hypersensitivity of drugs N.inadequate patients with whom physician evaluate
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method