Evaluation of Inner Ear and Brain Structures With Contrast-enhanced MRI in Patients With Meniere's Disease
- Registration Number
- NCT02530931
- Lead Sponsor
- University Hospital, Grenoble
- Brief Summary
* This prospective study aims to better characterize inner ear's perilymphatic structures with Magnetic Resonance Imaging using contrast media and delayed injection in patient's with Meniere's disease.
* MR Perfusion Imaging will be assess in both cochlea as well
* Primary auditory brain pathways will be evaluated through MR diffusion imaging
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- All
- Target Recruitment
- 23
Inclusion Criteria
- Major subjects of over 40 years (mean age of Meniere's disease 40 to 50 years)
- Informed consent signed
- Medical examination performed prior to participation in research
- Patients with clinical criteria of Meniere's disease according to the classification of the American Association of Otology (ie the combination of a sensorineural hearing loss at low frequencies, recurrent vertigo and tinnitus and / or clogged ear sensation)
- Recipient of a French social security scheme
Exclusion Criteria
- Patients minors
- Patients on a legal protection regime type guardianship
- Respiratory pathologies, cardiovascular, renal, diabetes
- Claustrophobia
- Contraindications to exposure to a magnetic field
- Contraindications to injecting Dotarem ®
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description patients with Meniere's disease Gadolinium -
- Primary Outcome Measures
Name Time Method Gadolinium enhancement in inner ear structures as measured by MR T1 Weighted-Imaging dynamic measurement One MR scan (4 hours)
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms does Gadolinium contrast enhance in Meniere's Disease MRI studies?
How does contrast-enhanced MRI compare to standard-of-care diagnostics for Meniere's Disease?
Which biomarkers correlate with inner ear structural changes in Meniere's Disease patients using diffusion imaging?
What adverse events are associated with Gadolinium-based contrast agents in inner ear imaging?
Are there combination therapies involving Gadolinium that improve Meniere's Disease outcomes compared to monotherapy?
Trial Locations
- Locations (1)
GrenobleUniversityHospital
🇫🇷Grenoble, France
GrenobleUniversityHospital🇫🇷Grenoble, France