Effect of Total Sleep Deprivation on Vascular Function
概览
- 阶段
- 不适用
- 干预措施
- 未指定
- 疾病 / 适应症
- Sleep Deprivation
- 发起方
- University of Florida
- 入组人数
- 23
- 试验地点
- 1
- 主要终点
- Endothelial function
- 状态
- 已完成
- 最后更新
- 2年前
概览
简要总结
Insufficient sleep is associated with an increased risk for cardiovascular disease. The causal mechanisms are currently unknown, but may include endothelial dysfunction. The purpose of this study is to examine the influence of sex and aging on the effects of total sleep deprivation on vascular function and whether exercise training attenuates these effects.
研究者
入排标准
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Endothelial function
时间窗: through study completion, an average of 1 month
Endothelial function will be determined using brachial artery flow-mediated dilation via high resolution duplex ultrasonography. Reactive hyperemia will be produced by inflating a forearm cuff to \~250 mmHg for 5 minutes followed by rapid deflation.
Microvascular function
时间窗: through study completion, an average of 1 month
Microvascular function will be assessed using the forearm blood flow response to submaximal handgrip exercise. Brachial artery blood flow and diameter will be assessed using Doppler ultrasound.
次要结局
- Central arterial stiffness(through study completion, an average of 1 month)
- Central arterial hemodynamics(through study completion, an average of 1 month)