Effect of Glucagon-like peptide-1 stimulation on the micro vessels of the heart in women with chest pain and no significant obstruction of major vessels of the heart.

Phase 1

Conditions: Patients with angina pectoris and coronary microvascular dysfunction without significant stenosis og major coronary vessels
MedDRA version: 18.0Level: LLTClassification code 10065566Term: Microvascular anginaSystem Organ Class: 100000004849
Therapeutic area: Diseases [C] - Cardiovascular Diseases [C14]

Registration Number: EUCTR2015-002153-35-DK

Lead Sponsor: Bispebjerg University Hospital

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: ot Recruiting

Sex: Female

Target Recruitment: Not specified

Inclusion Criteria

- Women aged 40-75 with angina-like symptoms assessed by the Seattle Angina Questionnaire (SAQ)
- Referred for ischemic heart disease (IHD) assessment with no significant coronary stenosis (>50%) at coronary angiography or CT-angiography
- Impaired coronary flow reserve assessed by echo Doppler flow
- BMI=25kg/m2

Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range 16
F.1.3 Elderly (>=65 years) yes
F.1.3.1 Number of subjects for this age range 17

Exclusion Criteria

- Allergy to dipyridamole, Teofyllamine or Liraglutide
- Previous myocardial infarction or revascularization
- No episodes of chest pain within 6 months before inclusion
- Diabetes (reported, noted in journal or patient on antidiabetic medication)
- Other causes of chest discomfort deemed highly likely
- LVEF<45
- Significant valvular disease
- Congenital heart disease
- severe co-morbidity with limited life-expectancy< 1 year
- Severe asthma
- Severe COPD
- Pregnancy (pregnancy test will be done at inclusion)
- No use of anticonception although in child-bearing age
- physical or mental disability
- active cancer
- significant renal (eGRF<60) or hepatic co-morbidity
- chronic alcohol abuse
- atrial fibrillation
- AV block>1st degree
- chronic or previous acute pancreatitis
- inflammatory bowel disease
- history of thyroid adenoma/carcinoma
- participation in other RCT if relevant for the present study.
- Language- or other barrier to giving informed consent
- No signed informed consent