Effects of radiation therapy on oral mucosa microcirculation in patients with malignant disease in the head and neck region.
Completed
- Conditions
- bloeddoorstroming in de microvateninflammation of oral mucous membrane.oral mucositis1007299010047079
- Registration Number
- NL-OMON39703
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 20
Inclusion Criteria
* Patients receiving radiotherapy with curative intent in the Department of Radiotherapy in The
Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital in Amsterdam
* Histology proven squamous cell carcinoma of the oropharynx and oral cavity.
* Informed consent from each participating patient.
* Patients older than 18 years.
Exclusion Criteria
* Patients receiving other cancer treatment besides radiotherapy: systemically (e.g. chemotherapy) or in the area that will be measured (e.g. surgery).
* Patients with insulin-dependent diabetes.
* Patients that did not sign informed consent
* Patients younger than 18 years
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>- capillary enumeration (i.e. counting of the capillary loops present in each<br /><br>visual field). From 5 captured video frames an average will be computed and<br /><br>recorded to represent the capillary density.<br /><br>- a close observation will be made of the morphology of the capillaries.<br /><br>Because we do not know what to expect here, this will be noted discriptively<br /><br>afterwards. </p><br>
- Secondary Outcome Measures
Name Time Method <p>-</p><br>