Evaluation the serum level of valproic acid in subarachnoid hemorrhage patients

Not Applicable

• Conditions: subarachnoid hemorrhage.; ruptured cerebral aneurysm

• Registration Number: IRCT2013091113572N3
• Lead Sponsor: Tehran University Of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 February 2018

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 25

Inclusion Criteria

Patients with subarachnoid hemorrhage; GCS = 12; Age over 18

Exclusion Criteria

Scr=1.5 mg/dl or urine output>0.5cc/Kg/hr; Plattlet count<100,000; INR=2; Albumin<3; Age >18; Liver Function Test>3×Normal Range; Mean Arterial Pressure<70; Occurance of seizure during the study; Previous CNS diseases such as Parkinson's, Multiple sclerosis, CNS tumors, Infections involving the brain and CNS; History of using anti-epileptic drugs; Pregnancy; History of urea cycle disorders

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Total serum concentration. Timepoint: after 4 hours, 12 hours, before the third dose ,before the XII dose and before the last dose. Method of measurement: blood sampling from cv-line/GS-MASS.

Secondary Outcome Measures

Name	Time	Method
nbound serum concentration. Timepoint: after 4 hours, 12 hours, before the third dose ,before the XII dose and before the last dose. Method of measurement: formula.;Volume of distribution. Timepoint: after 4 hours, 12 hours, before the third dose ,before the XII dose and before the last dose. Method of measurement: formula.;Clearance. Timepoint: after 4 hours, 12 hours, before the third dose ,before the XII dose and before the last dose. Method of measurement: formula.;2-ene-valproate as a metabolite. Timepoint: after 4 hours, 12 hours, before the third dose ,before the XII dose and before the last dose. Method of measurement: GS-MASS.;4-ene-valproate as a metabolit. Timepoint: after 4 hours, 12 hours, before the third dose ,before the XII dose and before the last dose. Method of measurement: GS-MASS.