Prediction Model of Vitamin D Deficiency

Completed

• Conditions: Critical Illness
• Interventions: Other: Admitted to intensive care units

• Registration Number: NCT05376774
• Lead Sponsor: National Taiwan University Hospital

Brief Summary

Many studies have pointed out that patients with vitamin D deficiency have a longer stay in the intensive care unit and a poor prognosis. Previous multi- center prospective observational study in Taiwan reveals that the prevalence of vitamin D deficiency in critically ill patients in northern Taiwan is 59%, and the prevalence of severe vitamin D deficiency is 18%. Several prediction models of vitamin D deficiency had been built for the general population but not patients admitted in intensive care units.

This multi-center retrospective study aims to develop and validate a score-based prediction model for severe vitamin D deficiency in critically ill patients. Investigators will review the data of previous multicenter, prospective, observational study. For temporal validation, the data will be divided into a derivation cohort (first 80% of the data set based on chronology) and a validation cohort (the remaining data set). The development and validation of the models will be carried out following the recommendations established in the Transparency Reporting of a multivariable prediction model for Individual Prognosis or Diagnosis (TRIPOD) initiative.

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2022-05-01
• Study First Submitted: 2022-05-12
• Study First Submitted QC: 2022-05-12
• Study First Posted: 2022-05-17
• Primary Completion: 2022-08-01
• Status Verified: 2022-09
• Study Completion: 2022-09-01
• Last Update Submitted: 2022-09-11
• Last Update Posted: 2022-09-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 662

Inclusion Criteria

• Patients admitted to intensive care units

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Exclusion Criteria

• aged < 20 years
• admitted to intensive care unit longer than 28 days
• body max index < 18 kg/m2
• receive vitamin D supplement > 3000 IU/day
• previously admitted to intensive care unit within 3 months
• have parathyroid disease, rickets, or severe liver cirrhosis [Child C]

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Critically ill patients	Admitted to intensive care units	Patients admitted to intensive care units

Primary Outcome Measures

Name	Time	Method
Performance of the score-based prediction model	1 day	Area under the receiver operating characteristic (AUROC) and area under precision recall curve (AUPRC) of the prediction models for severe vitamin D deficiency

Trial Locations

Locations (1)

Department of Anesthesiology, National Taiwan University Hospital; 🇨🇳 Taipei City, Taiwan