The Effects of Interrupting Prolonged Sitting With Intermittent Exercise on Postprandial Lipemia

Not Applicable

Completed

• Conditions: Hyperinsulinism; Glucose Metabolism Disorders; Metabolic Syndrome X; Insulin Resistance; Metabolic Disease; Atherosclerosis; Arterial Occlusive Diseases; Cardiovascular Diseases; Arteriosclerosis; Vascular Diseases
• Interventions: Behavioral: Prolonged sitting with interval exercise; Behavioral: Prolonged sitting without exercise

• Registration Number: NCT03856606
• Lead Sponsor: University of Texas at Austin

Brief Summary

The purpose of this study is to investigate the effect of interrupting prolong sedentary behavior with interval exercise on postprandial metabolism following a high fat glucose tolerance test.

Detailed Description

All subjects complete two trials in a randomized crossover design, with each trial occurring over 4 days with a minimum of seven days between trials. The first two days of each trial serve as a control period allowing for familiarization and the control of physical activity and calorie consumption prior to the intervention. Following each control period, subjects then perform one of the interventions on Day 3. The interventions consist of either eight-hours of prolonged sitting, or eight hours of sitting interrupted every hour by five sprints lasting 4 seconds each using the interval exercise. On day 4, all subjects will undergo a high fat glucose tolerance test to determine the body's ability to clear triglycerides from the blood as well as insulin/glucose response and substrate oxidation. Blood samples will be assayed for the previously mentioned substances and postprandial gas collection will be analyzed via indirect calorimetry.

Study Timeline

• Study Start: 2018-02-20
• Primary Completion: 2018-07-08
• Study Completion: 2018-07-08
• Status Verified: 2019-02
• Study First Submitted: 2019-02-25
• Study First Submitted QC: 2019-02-25
• Last Update Submitted: 2019-02-25
• Study First Posted: 2019-02-27
• Last Update Posted: 2019-02-27

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 8

Inclusion Criteria

Exclusion Criteria

• cardiovascular problems (e.g. pre-existing heart issues, coronary artery disease, hypertension, etc.)
• respiratory problems
• musculoskeletal problems that prevent prolonged sitting or exercise
• susceptibility to fainting
• Pregnancy

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Prolonged sitting with interval exercise	Prolonged sitting with interval exercise	Subjects will be asked to undergo prolonged sitting (\~14 hours) of 1 day and will be asked to perform interval exercise every hour on the hour.
Prolonged sitting without exercise	Prolonged sitting without exercise	Subjects will be asked to undergo prolonged sitting (\~14 hours) of 1 day and will not be asked to perform interval exercise.

Primary Outcome Measures

Name	Time	Method
Plasma Triglycerides	6-hours	Areas under the curve for triglyceride concentration will be calculated for hourly samples from a 6-hour lipid tolerance test

Secondary Outcome Measures

Name	Time	Method
Plasma Glucose	6-hours	Areas under the curve for glucose concentration will be calculated for hourly samples from a 6-hour lipid tolerance test
Plasma Insulin	6-hours	Areas under the curve for insulin concentration will be calculated for hourly samples from a 6-hour lipid tolerance test

Trial Locations

Locations (1)

University of Texas at Austin Human Performance Laboratory; 🇺🇸 Austin, Texas, United States