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临床试验/NCT03856606
NCT03856606已完成不适用

The Effects of Interrupting Prolonged Sitting With Intermittent Exercise on Postprandial Lipemia

University of Texas at Austin1 个研究点 分布在 1 个国家目标入组 8 人开始时间: 2018年2月20日最近更新:
适应症
干预措施

试验速览

阶段
不适用
状态
已完成
入组人数
8
试验地点
1
主要终点
Plasma Triglycerides

研究概览

简要总结

The purpose of this study is to investigate the effect of interrupting prolong sedentary behavior with interval exercise on postprandial metabolism following a high fat glucose tolerance test.

详细描述

All subjects complete two trials in a randomized crossover design, with each trial occurring over 4 days with a minimum of seven days between trials. The first two days of each trial serve as a control period allowing for familiarization and the control of physical activity and calorie consumption prior to the intervention. Following each control period, subjects then perform one of the interventions on Day 3. The interventions consist of either eight-hours of prolonged sitting, or eight hours of sitting interrupted every hour by five sprints lasting 4 seconds each using the interval exercise. On day 4, all subjects will undergo a high fat glucose tolerance test to determine the body's ability to clear triglycerides from the blood as well as insulin/glucose response and substrate oxidation. Blood samples will be assayed for the previously mentioned substances and postprandial gas collection will be analyzed via indirect calorimetry.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Crossover
主要目的
Prevention
盲法
None

入排标准

年龄范围
18 Years 至 40 Years(Adult)
性别
All
接受健康志愿者

入选标准

  • 未提供

排除标准

  • cardiovascular problems (e.g. pre-existing heart issues, coronary artery disease, hypertension, etc.)
  • respiratory problems
  • musculoskeletal problems that prevent prolonged sitting or exercise
  • susceptibility to fainting
  • Pregnancy

研究组 & 干预措施

Prolonged sitting without exercise

Experimental

Subjects will be asked to undergo prolonged sitting (~14 hours) of 1 day and will not be asked to perform interval exercise.

干预措施: Prolonged sitting without exercise (Behavioral)

Prolonged sitting with interval exercise

Experimental

Subjects will be asked to undergo prolonged sitting (~14 hours) of 1 day and will be asked to perform interval exercise every hour on the hour.

干预措施: Prolonged sitting with interval exercise (Behavioral)

结局指标

主要结局

Plasma Triglycerides

时间窗: 6-hours

Areas under the curve for triglyceride concentration will be calculated for hourly samples from a 6-hour lipid tolerance test

次要结局

  • Plasma Glucose(6-hours)
  • Plasma Insulin(6-hours)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Edward F. Coyle

Professor

University of Texas at Austin

研究点 (1)

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