A Prospective, Randomized, Clinical Trial Comparing the Efficacy of Sensi-IP Toothpaste With a Sodium Fluoride Toothpaste in the Treatment of Dentinal Hypersensitivity
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Dentinal Hypersensitivity
- Sponsor
- IR Scientific Inc.
- Enrollment
- 46
- Locations
- 1
- Primary Endpoint
- Change from baseline at Day 14 using the Schiff Airblast Sensitivity Score
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
The study is designed as a prospective, randomized, parallel arm, double blinded, pilot clinical trial.The primary objective is to evaluate the efficacy of Sensi-IP +NaF as compared to a NaF toothpaste in the reduction of dentin hypersensitivity in adult participants over 14 days. Study endpoints include Evaporative Air blast Stimuli (Schiff Airblast Sensitivity Score), Tactile Stimuli (Yeaple probe Assessment), Visual Analogue Scale Evaporative Stimuli and the occurrence of adverse events. The study will include 2 study arms: 1. Sodium fluoride toothpaste with Sensi IP (N=23) and 2. Sodium fluoride toothpaste (N=23). Total of 46 participants (ages 18-80 years) with at least one hypersensitive tooth in 2 different quadrants which are anterior to the molars will be enrolled.
Detailed Description
The Study design is a prospective, randomized, parallel arm, double blinded, single study site, proof of concept clinical trial. The study will include 2 study arms: 1) Brushing with sodium fluoride toothpaste with Sensi IP (N=23) and 2) Brushing with sodium fluoride toothpaste (N=23). A total of 46 adults (18 - 80 years of age) will be included in this clinical trial. To account for the potential of a 15% drop out, as many as 46 participants may be enrolled and treated with the goal of 20 participants per arm. Study procedures will take place at the following timelines shown below: Visit 1: Screening Visit -Informed consent; Screening for eligibility Visit 2: Baseline Day 1: 7 days post screening; (+/- 1 Day) -Confirm eligibility, 1st treatment with allocated product Visit 3 Day 2: 1 Day after Visit 2; (+1 Day) -Study Assessments Visit 4: Day 14 (14 days after Visit 2 ;+/ 2 Days) -Final Study Assessments and Study Exit
Investigators
Eligibility Criteria
Inclusion Criteria
- •Willing and able to abide by the terms of the consent form
- •Can independently sign informed consent
- •Participants 18-80 years old
- •Agree to abstain from any other desensitizing, (stannous fluoride, arginine, calcium phosphosilicate, nanohydroxy apatite, potassium nitrate and varieties) whitening or other dental procedures for the duration of the trial
- •Agree to refrain from all oral hygiene procedures (in addition to the Study Product) and chewing gum for 8 h prior to each scheduled visit and refrained from eating and drinking for 4 h prior to each visit (sips of water is allowed for taking routine medications).
- •Have at least two hypersensitive teeth (≥2 Schiff Airblast Sensitivity Score) consistent at screening and baseline.
- •Target Teeth:
- •Demonstrate cervical dentin exposure, which may be visible with the use of loupes
- •Are non-adjacent in 2 different quadrants, anterior to the molars.
Exclusion Criteria
- •Are pregnant (to be confirmed by an over-the-counter dipstick pregnancy test) or breast feeding
- •Have lip or tongue piercing which the subject is unwilling to remove for the duration of the study
- •Have an active oral ulcer (Aphthous ulcer) at the time of screening
- •Have undergone desensitizing treatment (stannous fluoride, arginine, calcium phosphosilicate, nanohydroxy apatite, potassium nitrate and varieties) within the 1 month preceding the screening visit
- •Have undergone tooth bleaching within 8 weeks of screening
- •Have undergone scale, polish, interventional dental procedures within 1 month of screening
- •Are currently undergoing orthodontics
- •Receiving concomitant medication/therapy that might affect dentine hypersensitivity, e.g., regular use (\>3X per week) of analgesics, antihistamines, non-steroidal anti-inflammatory drug, and selective serotonin reuptake inhibitor medication
- •Demonstrate severe bruxism as indicated by reported muscular pain
- •Reduced salivary flow as determined by clinical assessment and/or patient report, diagnosed with Sjogren's disease, received radiation therapy to the head or neck within a year or currently being on medications that may cause xerostomia
Outcomes
Primary Outcomes
Change from baseline at Day 14 using the Schiff Airblast Sensitivity Score
Time Frame: 14 Days
Schiff Airblast sensitivity score is mainly used to assess participant response to evaporated air stimuli. The scale is 0-3 and higher scores mean a worse outcome.
Secondary Outcomes
- Change from baseline at Day 14 using the Yeaple probe assessment(14 Days)
- Change from baseline at Day 14 using the Visual Analogue Score (VAS) for pain following evaporative stimuli(14 Days)