跳至主要内容
临床试验/CTRI/2023/12/060795
CTRI/2023/12/060795尚未招募不适用

NT-ProBNP: a novel predictor of cardiovascular risk in type 2 diabetes

Roche Diagnostics1 个研究点 分布在 1 个国家目标入组 302 人开始时间: 2024年1月1日最近更新:

试验速览

阶段
不适用
状态
尚未招募
发起方
入组人数
302
试验地点
1
主要终点
NT-ProBNP, fasting glucose, HbA1c, HDL, triglycerides, total cholesterol, LDL, micro-albuminuria, and creatinine

研究概览

简要总结

NT-proBNP (N-terminal pro-B-type natriuretic peptide) is a biomarker that has significant medical value in the assessment and management of cardiovascular diseases. The measurement of NT-proBNP levels in the blood provides valuable information for the risk, diagnosis, prognosis, and monitoring of various cardiovascular conditions. NT-proBNP levels have been found to provide valuable prognostic information in patients with acute coronary syndrome (ACS) and a risk predictor marker for CVD in type 2 diabetes patients. Elevated levels of NT-proBNP in CVD patients are associated with an increased risk of adverse cardiovascular events, including mortality. The measurement of NT-proBNP can help risk-stratify patients with heart failure and guide for superlative treatment decisions. The study aims to determine theNT-Pro BNP levels in type 2 diabetes patients with and without CVD in comparison to healthy controls in order to assess the risk of marker in CVD. The study also assess the differences between the three groups by evaluating the risk stratification of CVD in each group using a standard CVD risk tool. The outcome measures include the levels of NT-proBNP to find the risk of CVD. Also, the NT-ProBNP levels will be correlated with other markers such as fasting glucose, HbA1c, HDL, triglycerides, total cholesterol, LDL, micro-albuminuria, and creatinine to find their association. Risk stratification assessment for CVD using risk tools is also included in order to compare the risk analysis between the groups. Elevated levels of NT-proBNP in type 2 diabetes are associated with an increased risk of cardiovascular disease. The measurement of NT-proBNP can help risk-stratify patients with heart failure and guide for superlative treatment decisions.

研究设计

研究类型
Observational

入排标准

年龄范围
40.00 Year(s) 至 80.00 Year(s)(—)
性别
All

入选标准

  • Type 2 diabetes mellitus patients with or without cardiovascular disease of either gender.

排除标准

  • Subjects who had cancer and renal dysfunction, Pregnancy, Subjects with valvular, rheumatic, and congenital heart disease.

结局指标

主要结局

NT-ProBNP, fasting glucose, HbA1c, HDL, triglycerides, total cholesterol, LDL, micro-albuminuria, and creatinine

时间窗: Baseline

次要结局

  • Risk stratification assessment for CVD using risk tools(baseline)

研究者

发起方
Roche Diagnostics
申办方类型
Pharmaceutical industry-Indian
责任方
Principal Investigator
主要研究者

Sahana Shetty

Manipal Academy of Higher Education

研究点 (1)

Loading locations...

相似试验

Evaluation of NT-ProBNP marker to predict the... | 临床试验