The Clopidogrel and Aspirin After Surgery for Coronary Artery Disease
- Registration Number
- NCT00776477
- Lead Sponsor
- China National Center for Cardiovascular Diseases
- Brief Summary
Clopidogrel is a antiplatelet agent and is effective at reducing intimal hyperplasia in animal models of thrombosis.Several large clinical trials have demonstrated that clopidogrel with aspirin can reduce ischemic events and mortality in patients with atherosclerotic disease,therefore the combination of two antiplatelets might be useful to prevent patients received coronary artery bypass graft surgery from Saphenous vein graft disease. the aim of this study is to estimate the safety and efficacy of clopidogrel and aspirin therapy versus aspirin alone in patients after CABG.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 300
Inclusion Criteria
- Patients undergoing primary multi-vessel CABG with at least two saphenous vein grafts, with or without the use of cardiopulmonary bypass.
Exclusion Criteria
- Emergency surgery
- Valve surgery
- Redo CABG
- Left ventricle ejection fraction < 30%
- Preoperative use of clopidogrel (with the exception of the current admission)
- Preoperative use of warfarin
- Allergy to aspirin or clopidogrel
- History of cerebrovascular accident
- History of severe liver disease
- Morbid obesity
- Current malignancy
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description 1 clopidogrel and aspirin - 2 aspirin -
- Primary Outcome Measures
Name Time Method Vein graft patency examined by CT scan three months after surgery
- Secondary Outcome Measures
Name Time Method Incidence of major adverse coronary events Incidence of major bleeding events two years following surgery
Trial Locations
- Locations (1)
Institute of cardiovascular diseases,Fuwai hospital
🇨🇳Beijing, Beijing, China