The Effect of Curcumin for Treatment of Cancer Anorexia-Cachexia Syndrome in Patients With Stage III-IV of Head and Neck Cancer
Phase 2
Completed
- Conditions
- Head and Neck NeoplasmsCancer CachexiaHead and Neck Cancer
- Registration Number
- NCT04208334
- Lead Sponsor
- Phramongkutklao College of Medicine and Hospital
- Brief Summary
A study of Curcumin to prevent cancer anorexia and cachexia Syndrom in locally advance and advance stage head and neck cancer (stage III, IV)
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 20
Inclusion Criteria
- Head and neck cancer stage III-IV
- Cancer anorexia cachexia syndrome by 2011 Cancer cachexia an International Consensus
- Enteral feeding with Nasogastric Tube or Gastrostomy
- ECOG 0-2
- Normal Bone marrow, kidneys, and liver function
- Normal function of enteral digestion and absorption
Exclusion Criteria
- Pregnancy
- History of allergy to Curcumin or herbal medicine
- History of Herbal medicine used
- History of Billiary of obstruction
- History of Antiplatelete or anticoagulant.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Muscle mass 60 days after intervention We measure muscle mass by Bioelectrical Impedance Analysis (BIA)
- Secondary Outcome Measures
Name Time Method BMI 60 days after intervention We measure BMI by Bioelectrical Impedance Analysis (BIA)
Hand grips muscle strength 60 days after intervention We measure hand grips power by Hand grip test
serum NF-kB level 60 days after intervention We measure serum NF-kB by ELISA
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms does curcumin target to alleviate cancer anorexia-cachexia syndrome in head and neck cancer patients?
How does curcumin compare to standard-of-care treatments for managing cachexia in stage III-IV head and neck cancer?
Are there specific biomarkers that predict curcumin response in advanced head and neck cancer patients with cachexia?
What adverse events are associated with curcumin therapy in head and neck cancer cachexia and how are they managed?
What combination therapies or alternative compounds show promise alongside curcumin for treating head and neck cancer anorexia-cachexia syndrome?
Trial Locations
- Locations (1)
Phramongkutklao Hospital
🇹🇭Ratchathewi, Bangkok, Thailand
Phramongkutklao Hospital🇹🇭Ratchathewi, Bangkok, Thailand