JPRN-UMIN000036424
Completed
N/A
An observational study to evaluate clinical utility of the pursuit of RAS status using ctDNA analysis to investigate the optimal patient population for anti-EGFR re-challenge therapy - REMARRY Study
ational Cancer Center Hospital East0 sites180 target enrollmentApril 18, 2019
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Patients with RAS/BRAF V600E wild-type unresectable advanced or recurrent colorectal cancer who have been treated with anti-EGFR monoclonal antibody
- Sponsor
- ational Cancer Center Hospital East
- Enrollment
- 180
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- •1\)Severe comorbidity. (a)Active multiple cancer (b)Uncontroled central nervous system or leptomeningeal metastasis (c)Mental illness or mental symptoms that would interfere with participation in the study 2\)Any patients who are regarded as inadequate for anti\-EGFR monoclonal antibody re\-challenge by investigators. 3\)Intolerant to previous irinotecan therapy. 4\)Comorbidity or history of severe pulmonary disease. 5\)Men/women who are unwilling to avoid pregnancy. Women who are pregnant or breastfeeding. Women with a positive pregnancy test. 6\)Active HCV or HIV infection. 7\)Any other patients who are regarded as inadequate for study enrollment by investigators.
Outcomes
Primary Outcomes
Not specified
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