Myocardial Physiology And Microanatomy In Individuals Undergoing Heart Surgery

Not Applicable

Completed

• Conditions: Myocardial Injury
• Interventions: Behavioral: Exercise training; Procedure: remote ischemic preconditioning

• Registration Number: NCT01308138
• Lead Sponsor: Norwegian University of Science and Technology

Brief Summary

The main focus of the project is to determine to what degree myocardial energy metabolism is linked to impaired function in human cardiomyocytes, whether exercise training and remote ischemic preconditioning can restore cardiomyocyte function and whether this is linked to improved mitochondrial and cell function.

Detailed Description

Not available

Study Timeline

• Study Start: 2011-01
• Study First Submitted: 2011-02-02
• Study First Submitted QC: 2011-03-02
• Study First Posted: 2011-03-03
• Primary Completion: 2013-05
• Study Completion: 2013-07
• Status Verified: 2015-08
• Last Update Submitted: 2015-08-19
• Last Update Posted: 2015-08-20

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• Patients undergoing coronary heart surgery and heart transplantation

Exclusion Criteria

• myocardial infarction closer than 4 weeks to project start, serious valve defects, diabetes, unstable angina, uncontrolled hypertension, kidney failure (creatinin > 140)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
ExerciseTr	Exercise training	-
Remote ischemic preconditioning group	remote ischemic preconditioning	-

Primary Outcome Measures

Name	Time	Method
Mitochondrial respiration	1 hour	Oxygraph (Strathkelvin)

Trial Locations

Locations (1)

Norwegian University of Science and Technology, Medical Faculty; 🇳🇴 Trondheim, Sør-Trondelag, Norway