Predisposition to Persistent Pain After Orthopaedic Surgery: Genetic Aspects

Completed

• Conditions: Chronic Pain

• Registration Number: NCT01989351
• Lead Sponsor: ASST Gaetano Pini-CTO

Brief Summary

The study purpose is to examine polymorphism of genes associated to post-operative persistent pain and to verify the possible association between genotype phenotype and ADRB2 polymorphism in orthopaedic surgery. The primary aim is to evaluate the expression of ADBR2 in VAS\>4 patients and to compare it to those with VAS\<4.

Detailed Description

Not available

Study Timeline

• Study Start: 2013-03
• Study First Submitted: 2013-11-05
• Study First Submitted QC: 2013-11-14
• Study First Posted: 2013-11-21
• Status Verified: 2017-02
• Primary Completion: 2017-02-06
• Study Completion: 2017-02-06
• Last Update Submitted: 2017-02-06
• Last Update Posted: 2017-02-07

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 130

Inclusion Criteria

• age > 18
• ASA I to III

Exclusion Criteria

• Contraindications to regional anesthesia procedures
• Not stabilized neurological diseases
• Diabetes

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Frequency of SNPs rs12654788 and rs1042713 of ADBR2 gene in patients who complain persistent pain 4 months postoperatively compared to chronic pain free patients.	4 months after surgery

Secondary Outcome Measures

Name	Time	Method
Expression frequency of OPRM1, COMT, IL1Ra	6, 12, 24, 48 hours
Serum concentration of TNFα, TGFβ, IFNγ, IL-6 and IL-10 obtained with ELISA system	6, 12, 24 and 48 hours postoperatively

Trial Locations

Locations (1)

Istituto Ortopedico G. Pini; 🇮🇹 Milan, Milano, Italy