NCT01670396Unknown不适用
G Protein β3 Subunit (GNB3) Polymorphism and Restenosis of Coronary Drug-eluting Stents
Shanghai Zhongshan Hospital1 个研究点 分布在 1 个国家目标入组 300 人开始时间: 2012年3月最近更新:
适应症
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 300
- 试验地点
- 1
- 主要终点
- In-stent restenosis
研究概览
简要总结
The investigators hypothesized that genetic variants of G protein influence the development of restenosis and clinical outcome of patients receiving drug-eluting stents (DES).
详细描述
Although drug-eluting stents (DES) have reduced restenosis rates compared with bare-metal stents, the restenosis rate is still high in the high-risk group. G protein plays important roles in the signal transduction leading to vascular smooth muscle proliferation. The initial and subsequent studies suggest that the T allele of C825T polymorphism is associated with enhanced transmembrane signaling via Gi proteins.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients who underwent follow-up angiography. All the patients must had been implanted with DES during the last two years.
排除标准
- •For the non-ISR group, the patients underwent follow-up angiography less than 6 months away from stent implanting.
结局指标
主要结局
In-stent restenosis
时间窗: 6-24months after stent implanting
次要结局
- target lesion revascularization (TLR)(6-24months after stent implanting)
- re-myocardial infarction(6-24months after stent implating)
研究者
研究点 (1)
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