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临床试验/NCT04584827
NCT04584827已完成不适用

Evaluation of Lactate in Patients Undergoing Glial and Non Glial Mass Surgery With Craniotomy

Trakya University1 个研究点 分布在 1 个国家目标入组 100 人开始时间: 2019年12月10日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
100
试验地点
1
主要终点
lactate level

研究概览

简要总结

The aim of this study is to determine the effects of the level of metabolites used in routine on mortality and morbidity in patients who will undergo intracranial surgery with craniotomy.

详细描述

In this study, in patients who are planned to have an intracranial mass operation with craniotomy, their medical histories, demographic features, comorbidities, preoperative radiotherapy treatment, the parameters examined in the preoperative routine will be collected as a file scan (previous operations, GKS, laboratory values). The classification of patients according to the 2016 World Health Organization Central Classification of Nervous System Tumors (WHO-CNS classification) and whether it is glial or non glial will be recorded from the clinical file. Intraoperative; hemodynamic data of patients; heart rate, diastolic, systolic and mean arterial pressures, fluid and blood products delivered, anesthetic and other medications, and blood gas samples will be written from the anesthesia document after the operation is finished. For the study, the application of the anesthesiologist for the patient will not be interfered. If postoperative patients are sent to the intensive care unit, their laboratory values and clinical observations (mortality, morbidity, neurological sequelae, imaging techniques, GOSE (Glasgow outcome skale)) will be recorded. In our study, mortality and morbidity will be evaluated 30 days postoperatively, and if the patient was sent to the service from the intensive care unit in this process, the values in the postoperative clinic (mortality, morbidity, neurological evaluation, imaging techniques, pathology results) will be recorded from the patient document. If the patient was discharged 30 days before, outpatient data will be recorded. The patients will be classified by evaluating the collected data (intraoperative hemodynamic data, blood transfusions, postoperative neurological sequel, postoperative complications and mortality).

In our study; the effects of lactate level on mortality and morbidity will be investigated in patients undergoing an intracranial mass operation with general anesthesia.

研究设计

研究类型
Observational
观察模型
Other
时间视角
Prospective

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Having an intracranial mass operation with craniotomy
  • No history of congestive heart failure
  • No kidney and liver dysfunction
  • Not pregnant
  • Not taking inotropic drugs during the operation
  • Receiving less than four red blood product replacements during the operation

排除标准

  • Patients with a history of congestive heart failure
  • Patients with kidney and liver dysfunction
  • Patients who need an inotropic agent to adjust blood pressure during the operation
  • Patients who have undergone four or more red blood product transfusions during the operation
  • Pregnant patients

结局指标

主要结局

lactate level

时间窗: change from operation to post-op second day (4 time)

Lactate, a byproduct of glycolysis, is an indicator of weak tissue perfusion and a useful biomarker with prognostic value in various diseases. Lactate value is calculated by blood gas.

次要结局

  • Glasgow Outcome Scale(30 days after the operation (1 time))

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Onur Kucuk

Department of anesthesiology and reanimation, Research Assistant

Trakya University

研究点 (1)

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