Effect of vitamin D in enhanced recovery after brain surgery
Phase 3
Recruiting
- Conditions
- Patients with brain tumors who have candidate for craniotomy surgery.Malignant neoplasm of brain
- Registration Number
- IRCT20190126042496N1
- Lead Sponsor
- eurofunctional Reseach Center of Shohada Tajrish Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
The willingness to cooperate and complete the informed consent form by the patient or legal surrogate
The patient's age = 18
Definitive diagnosis of brain tumor and need craniotomy for resection
Levels of 25-OHD = 20 ng/mL for intervention group
Levels of 25-OHD > 30 ng/mL for normal group
Exclusion Criteria
Unwillingness to co-operate by the patients or their surrogate at the beginning of the study
Participation in other clinical trials at the same time with this study
Pregnancy and lactation
Hypercalcemia
Hyperphosphatemia
Tuberculosis
Sarcoidosis
History of nephrolithiasis
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Changes in serum levels of 25OHD before and after injection and surgery. Timepoint: Measurement of serum levels of 25OHD at the beginning of the study in all patients. Measurement of serum levels of 25OHD on the fifth day after surgery in intervention group who received a single high dose of vitamin D prior to surgery. Method of measurement: Laboratory measurements of 25OHD serum levels using Monobind kit by Enzyme-Linked Immunosorbent Assay (ELISA) method.
- Secondary Outcome Measures
Name Time Method