Non-invasive Prediction of Fluid and Noradrenaline Responsiveness in Critical Care Patients Using the Carotid Wave Intensity (cWI)
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 120
- 试验地点
- 1
- 主要终点
- The prediction of the hemodynamic response to norepinephrine or fluids using carotid ultrasound measurements.
研究概览
简要总结
The goal of this observational study is to study a new method to compute ventricular-arterial coupling (VAC) in adult intensive care patients after cardiac surgery. VAC is a metric that describes the interaction between the heart and the arterial system. The new method of measuring VAC uses carotid ultrasound measurements. The main questions this study aims to answer are:
- Can VAC measured using carotid ultrasound predict the hemodynamic response to drugs?
- What is the concordance of VAC measurements obtained via carotid ultrasound with VAC measurements obtained via the standard, single-beat method? Measurements will be performed in the operating room and at the ICU.
详细描述
The goal of this prospective observational study is to study ventricular-arterial coupling (VAC) measured using carotid ultrasound in adult intensive care patients after cardiac surgery. The objectives of this study are:
- To determine if VAC measured using carotid ultrasound can predict the hemodynamic response to drugs.
- To assess and quantify the concordance of VAC measurements obtained using carotid ultrasound with VAC measurements obtained using the single-beat method.
Measurements will be performed in the operating room and at the ICU.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Crossover
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult patients (≥18 years)
- •Admitted to the ICU after cardiac surgery
排除标准
- •No informed consent for study participation
- •Within the first 3 hours of ICU admission noradrenaline infusion is not increased or started, and/or a fluid bolus is not given; both on indication of the attending physician
- •Patient with chronic obstructive pulmonary disease (COPD) gold stage 3 or 4
- •Pregnancy
- •Moderate to severe aortic valve disease
- •Atrial fibrillation
- •Carotid artery stenosis >50%
- •History of cerebrovascular accident or transient ischemic attack
- •History of cerebral trauma
- •Morbid obesity (BMI >40 kg/m2)
- •Emergency surgery
结局指标
主要结局
The prediction of the hemodynamic response to norepinephrine or fluids using carotid ultrasound measurements.
时间窗: Through study completion, an average of 1 year.
It will be studied if carotid ultrasound measurements can be used to predict a hemodynamic response to hemodynamic drugs, where the hemodynamic response is defined as a 15% increase in stroke volume.
次要结局
- The concordance of ventricular-arterial coupling (VAC) measurements obtained using carotid ultrasound measurements with VAC measurements obtained using the single-beat method.(Through study completion, an average of 1 year.)
研究者
Frederique de Raat
Principal Investigator
Catharina Ziekenhuis Eindhoven