Characterization of Obesity-related Cardiomyopathy Through Exploration of Human Atrial Trabeculae Contraction
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 134
- 试验地点
- 1
- 主要终点
- Intrinsic myocardial contractile force
研究概览
简要总结
The investigators aim to explore obese cardiomyopathy by studying contractile twitch force, sarcomere sensitivity to calcium and mitochondrial function in atrial myocardial samples of patients grouped according to their body mass index, i.e. normal weight, overweight and obese.
详细描述
Obesity is associated with the development of heart failure, regardless of coronary artery disease or other comorbidities.
Right atrial samples obtained from patients undergoing cardiac surgery and presenting no sign of clinical cardiomyopathy will be grouped according to patient's body mass index. Atrial trabeculae will be explored to dissect out the respective contribution of (i) sarcoplasmic reticulum dysfunction (isometric twitch force contraction analysis), (ii) abnormal sarcomere sensitivity to calcium assessed in permeabilized fibers and (iii) mitochondrial dysfunction to intrinsec contractile dysfunction of myocardium in obese patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patient schedulled for coronary artery bypass graft surgery or aortic valve replacement surgery with extracorporeal circulation
- •must be over 18 years of age
- •must be able to read and understand the consent form in French
- •must be in sinus rhythm at inclusion time
排除标准
- •medical history of type 1 diabetes
- •medical history of sustained atrial arrhythmia
- •pregnancy
- •class III anti-arhythmic drug
结局指标
主要结局
Intrinsic myocardial contractile force
时间窗: the day of cardiac surgery
twitch force developed by atrial trabeculae assessed in isometric conditions in atrial samples
次要结局
- sarcomere sensitivity to calcium(the day of cardiac surgery)
- Mitochondrial function(the day of cardiac surgery)