LABORATORY STUDIES OF SOFT TISSUE SARCOMAS
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Sarcoma
- Sponsor
- University of Arizona
- Enrollment
- 27
- Locations
- 1
- Primary Endpoint
- Identification of molecular targets that would improve the diagnosis, prognosis, and/or treatment of STS
- Status
- Completed
- Last Updated
- 12 years ago
Overview
Brief Summary
RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
PURPOSE: This research study is looking at tumor tissue samples from patients with soft tissue sarcoma.
Detailed Description
OBJECTIVES: * To develop a pilot program for the collection, archiving, and experimental analyses of soft tissue sarcomas (STS). * To obtain STS tumors from cancer patients undergoing tumor removal or core needle biopsies. * To evaluate cellular and molecular factors involved in STS oncogenesis by studying samples derived from human tumor specimens. * To develop an accompanying bioinformatics database of the demographics of STS patients from which tumor specimens are derived for experimental study. OUTLINE: Tumor tissue samples are analyzed for gene and protein expression by cDNA microarray analysis, RT-PCR, immunohistochemistry, in vitro transformation assays, RNA interference, and Western blot or immunoprecipitation.
Investigators
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Identification of molecular targets that would improve the diagnosis, prognosis, and/or treatment of STS
Time Frame: 3 months