Studying Tumor Tissue Samples From Patients With Soft Tissue Sarcoma
- Conditions
- Sarcoma
- Registration Number
- NCT00900341
- Lead Sponsor
- University of Arizona
- Brief Summary
RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
PURPOSE: This research study is looking at tumor tissue samples from patients with soft tissue sarcoma.
- Detailed Description
OBJECTIVES:
* To develop a pilot program for the collection, archiving, and experimental analyses of soft tissue sarcomas (STS).
* To obtain STS tumors from cancer patients undergoing tumor removal or core needle biopsies.
* To evaluate cellular and molecular factors involved in STS oncogenesis by studying samples derived from human tumor specimens.
* To develop an accompanying bioinformatics database of the demographics of STS patients from which tumor specimens are derived for experimental study.
OUTLINE: Tumor tissue samples are analyzed for gene and protein expression by cDNA microarray analysis, RT-PCR, immunohistochemistry, in vitro transformation assays, RNA interference, and Western blot or immunoprecipitation.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 27
Not provided
Not provided
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Identification of molecular targets that would improve the diagnosis, prognosis, and/or treatment of STS 3 months
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Arizona Cancer Center at University of Arizona Health Sciences Center
🇺🇸Tucson, Arizona, United States