We are here to compare the use of IV magnesium sulphate and bupivacaine scalp block to reduce the frequent change in blood pressure and heart rate in patients undergoing head surgery under general anaesthesia.

Not yet recruiting

• Conditions: Other specified disorders of nervous system in diseases classified elsewhere,

• Registration Number: CTRI/2020/10/028199
• Lead Sponsor: ABVIMS and Dr RML Hospital

Brief Summary

This study is a randomized comparative study comparing IV magnesium sulphate @50mg/kg in 100 ml Normal saline over 10 min and  Bupivacaine scalp block(20-30ml 0f 0.5%)local infiltration at pin insertion site in 60 patients(30 in each group)for attenuation of hemodynamic response following scalp pin insertion in patients undergoing craniotomy under general anaesthesia.It is conducted at Atal Bihari Vajpaiyee Institute Of Medical Sciences and Dr RML Hospital,New Delhi,India.

The primary outcome to measure MAP and Heart rate at various interval of time after application of pins.The secondary outcome to look for any need of rescue drug for attenuating hemodynamic response and adverse effect of drugs.

Detailed Description

Not available

Study Timeline

• Study Start: 2020-06-10
• Last Update Posted: 2020-09-25

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• ASA physical status I and II.
• Scheduled for elective craniotomies.

Exclusion Criteria

• 1.Emergency surgeries 2.Intracranial aneurysm surgery.
• 3.History of magnesium sulphate consumption or allergy.
• 4.Allergy to bupivacaine.
• 5.Renal and Hepatic disease.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
MAP and HR	Baseline,at the time of pin insertion,5s,10s,30s,60s,120s,180s,300s,10min,15min and 30min after pin insertion.

Secondary Outcome Measures

Name	Time	Method
1.To look for any need of rescue drug used for attenuating hemodynamic response(0.5mg/kg propofol)	2.Adverse effect of drugs.

Trial Locations

Locations (1)

ABVIMS And Dr.RML Hospital; 🇮🇳 Delhi, DELHI, India

ABVIMS And Dr.RML Hospital

🇮🇳Delhi, DELHI, India

Dr Astha sahu

Principal investigator

9560183218

dr.asthasahu09@gmail.com