Randomised double blind study of comparing two weight adjusted doses of norepinephrine for preventing hypotension during spinal anaesthesia for elective Caesarean section
试验速览
- 阶段
- 2/3 期
- 状态
- 已完成
- 发起方
- 入组人数
- 170
- 试验地点
- 1
- 主要终点
- 1)Doses of rescue bolus of phenylephrine 20 mcg
研究概览
简要总结
Hypotension is the most common complication seen in patients undergoing Caesarean section under spinal anaesthesia.Norepinephrine infusion has been suggested as an effective method for preventing hypotension during spinal anaesthesia for elective Caesarean section. Norepinephrine associated with less propensity to reduce heart rate and cardiac output owing to its mild beta adrenergic agonist effects.our study compares norepinephrine infusion with two different combinations in elective Caesarean section under spinal anaesthesia
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Participant and Outcome Assessor Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 35.00 Year(s)（—）
- 性别
- Female
入选标准
- •full term women undergoing elective cesarean section 2) ASA class II 3)age between 18-35 years.
排除标准
- •patients refusal 2)hypertensive disorders 3)cardiac diseases 4)allergy to local anaesthetics 5)obstretic complications (antepartum hemorrhage,placenta privea,placental abruption) 6)coagulopathy,sepsis,hepatic or renal failure.
结局指标
主要结局
1)Doses of rescue bolus of phenylephrine 20 mcg
时间窗: Incidence of hypotension is assessed immediately after spinal anaesthesia measurement of blood pressure every 1 minute after spinal till the delivery of baby and the amount of PHENYLEPHERINE boluses used during the intraoperative period.
2)access incidence of hypotension in both groups
时间窗: Incidence of hypotension is assessed immediately after spinal anaesthesia measurement of blood pressure every 1 minute after spinal till the delivery of baby and the amount of PHENYLEPHERINE boluses used during the intraoperative period.
次要结局
- 1)intraoperative blood pressure(systolic and diastolic h(Pressure))