Heart Failure with Preserved Ejection Fraction (HFpEF), a prospective cohort

Completed

• Conditions: hartaandoeningen, falen van de hartfunctie; Heart failure with preserved ejection fraction; 10082206

• Registration Number: NL-OMON50023
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Trial ended prematurely

Detailed Description

Not available

Study Timeline

• Results First Posted: 2021-01-07
• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 201

Inclusion Criteria

All patients referred with exertional dyspnea to the HFpEF clinic from the
general HF, general cardiology outpatient clinic or directly from their general
practitioners above 18 years that have the ability to give the informed consent
and sign it will be included in the cohort and blood and urine samples for the
biobank will be obtained. , 20 hypertensive control patients will be included.
These are their inclusion criteria:
o Age > 50 years
o Estimated glomerular filtration reserve (eGFR) >30 ml/min
o Body weight<130kg
o No coronary artery disease (CAD; coronary stenosis>70% or history of CABG)
o No heart failure
o Preserved left ventricular ejection fraction (LVEF) (>= 50%) on
echocardiography
o No left ventricular hypertrophy (lateral and septal left ventricular wall
=<10mm)
o No left atrium enlargement
o No diastolic dysfunction type 2 or 3
o Blood pressure >140/90 mmHg or use of anti-hypertensive therapy
o Normal cardiac structure and function on echocardiography

Exclusion Criteria

- Inability to give informed consent or refusal to participate in the study
- Age <18 years.

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>(1) Set up a cohort of HFpEF patients with an detailed clinical<br /><br>characterization of their phenotype. </p><br>