The Impact of a Low or High Phosphate Diet on Phosphate and Calcium Excretion in Healthy People
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- Urinary phosphate excretion
研究概览
简要总结
Phosphate is present in many of the foods that the investigators eat and is required by many cellular processes. The kidneys are the only organ that excrete the extra phosphate from the diet that the body does not require. Phosphate is linked to vascular calcification and cardiovascular disease. Measures of serum phosphate do not reflect the burden of phosphate and are not sensitive to early changes in the way the kidneys eliminate phosphate. This study will determine whether the kidneys handle an oral phosphate load differently after 5 days of a low phosphate diet compared to 5 days of a high phosphate diet.
详细描述
In this study, participants will follow a low-phosphorus diet (750 mg) with a 500 mg calcium supplement for 5 days keeping a detailed diary of the foods eaten during this period. On the 5th day, the participant will undergo a 24 hour urine collection. Participants will present after an overnight fast for baseline blood and urine measurements. Then they will consume water containing 500 mg of phosphorus. Urine and blood will be collected every hour for 3 hours for measurement of phosphate and calcium and for measurement of hormones known to regulate phosphate and calcium including fibroblast growth factor-23, parathyroid hormone and vitamin D. One week later, participants will follow the same diet but will also receive a 1250 mg phosphorus supplement for 5 days. On the 5th day, urine will be collected for 24 hours. Participants will present again after an overnight fast and undergo the identical testing.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •between ages of 20 and 40
排除标准
- •known heart disease
- •known diabetes
- •breast-feeding
研究组 & 干预措施
Phosphate supplemented diet
All participants will undergo phosphate testing after following a phosphate supplemented diet for 5 days
干预措施: Phosphate supplemented diet (Dietary Supplement)
Low phosphate diet
All participants will undergo phosphate testing after following a low phosphate diet for 5 days
结局指标
主要结局
Urinary phosphate excretion
时间窗: 3 hours
Change in urinary phosphate excretion after 500 mg phosphorus challenge
次要结局
未报告次要终点
研究者
Dr. Rachel Holden
Professor of Medicine Queen's University
Clinical Evaluation Research Unit at Kingston General Hospital