The Effect of Esmolol on Tissue Perfusion and Clinical Prognosis of Patients With Severe Sepsis: a Prospective Cohort Study .
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 151
- 主要终点
- The survival time of patients more than 28 days is defined as survival. The survival time of patients less than 28 days is defined as death.
研究概览
简要总结
The purpose of this study was to investigate the effect of esmolol on hemodynamic parameters,tissue perfusion and the clinical prognosis of patients with severe sepsis
详细描述
enrollment:151 patients
Inclusion criteria: (1) age > 18 years; (2) severe sepsis (acute organ dysfunction secondary to infection )diagnosis according to Campaign to Save Septic Patients: 2008 Treatment Guidelines for Severe Sepsis and Septic Shock, who (3) mechanical ventilation via endotracheal intubation with a tidal volume of 6 mL/kg; and (4) satisfactory sedation and analgesic treatment, with HR > 100 bpm.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •age > 18 years;
- •severe sepsis (acute organ dysfunction secondary to infection )diagnosis according to Campaign to Save Septic Patients: 2008 Treatment Guidelines for Severe Sepsis and Septic Shock,
- •mechanical ventilation via endotracheal intubation with a tidal volume of 6 mL/kg;
- •satisfactory sedation and analgesic treatment, with HR > 100 bpm.
排除标准
- •pre-existing cardiac dysfunction, valvular heart disease, high-degree atrioventricular block;
- •acute or chronic pulmonary heart disease;
- •a history of serious asthma;
- •chronic renal insufficiency;
- •cancer, autoimmune diseases, or contraindications for placement of deep venous catheter;
- •insulin-dependent diabetes.
研究组 & 干预措施
esmolol group
patients in the esmolol group received continuous infusion of esmolol via a micro-pump through a catheter placed in the superior vena cava.
干预措施: Esmolol (Drug)
control group
Control group also received natural saline via a micro pump, in the same way the esmolol group received esmolol.
干预措施: natural saline (Drug)
结局指标
主要结局
The survival time of patients more than 28 days is defined as survival. The survival time of patients less than 28 days is defined as death.
时间窗: 28 days
次要结局
未报告次要终点
研究者
Xiuling Shang
the ethic committee of Fujian Provincial Hospital
Fujian Provincial Hospital