The Influence of Treatment Position (Prone vs. Supine) on Whole Breast Irradiation for Chinese Breast Cancer Patients :Comparative Study
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 300
- 试验地点
- 1
- 主要终点
- dose distribution of GTV
研究概览
简要总结
Radiotherapy after breast conserving therapy plays an important role in early stage breast cancer patients. It not only results in a reduction in local and regional recurrence but also decrease the death rate effectively. For adjuvant radiotherapy, supine positioning is the most common approach and has multiple advantages. Due to deformability and softness of the breast, during simulation and treatment in supine position, the breast stretches over the chest wall, especially in patients with large and pendulous glands. Thus the organs at risk (OARs) received dose increased. The radiotherapeutic toxicity are unavoidable. Some present studies show that the prone positioning of patients can improve dose homogeneity and reduce the dose distribution in OARs in patients with large and pendulous glands. Chinese women have relatively small breasts, the advantages of those have not been established. Therefore, investigators compared the parameters between supine and prone positions for whole breast irradiation after conserving surgery.
详细描述
Objective To investigate the difference of target volumes and dosimetric parameters between supine and prone positions for whole breast irradiation after conserving surgery.
Methods Breast cancer patients with T1-2N0M0 stage who underwent radiation therapy after conserving surgery were enrolled. Supine and Prone scan sets were acquired during free breathing for all patients. Target volumes and organs at risk (OARs) including heart, ipsilateral lung and bilateral breast were contoured by the same radiation oncologist. The tumor bed (TB) was determined based on surgical clips. The Clinical target volume (CTV)consisted of the whole breast. The planning target volume (PTV) was CTV plus 0.5cm. The boost of PTV (PTVboost) was TB plus 0.5cm. Dosimetric parameters of target volumes and OARs were compared between supine and prone position.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years(Adult, Older Adult)
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Breast cancer patients with T1-T2N0M0 stage who underwent radiation therapy after conserving surgery
- •exhibited normal arm movement aſter surgery
- •had no chronic lung diseases
- •Written informed consent forms
排除标准
- •Breast cancer patients with radical surgery
- •could not exhibit normal arm movement after surgery
- •had chronic lung diseases
- •refused informed consent forms
结局指标
主要结局
dose distribution of GTV
时间窗: 1 year
the difference of GTV (Gross tumor target) between two plans
dose distribution of CTV
时间窗: 1 year
the difference of CTV (clinical target volume) between two plans
dose distribution of ipsilateral lung
时间窗: 1 year
the difference of ipsilateral lung dose distribution between two plans
dose distribution of heart
时间窗: 1 year
the difference of heart dose distribution between two plans
dose distribution of bilateral breasts
时间窗: 1 year
the difference of bilateral breasts dose distribution between two plans
dose distribution of PTV
时间窗: 1 year
the difference of PTV (planing target volume) between two plans
次要结局
未报告次要终点
研究者
NING_LI
professor
Cancer Institute and Hospital, Chinese Academy of Medical Sciences
