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Clinical Trials/NCT05609058
NCT05609058
Recruiting
Not Applicable

The Influence of Treatment Position (Prone vs. Supine) on Whole Breast Irradiation for Chinese Breast Cancer Patients :Comparative Study

Cancer Institute and Hospital, Chinese Academy of Medical Sciences1 site in 1 country300 target enrollmentJanuary 1, 2019
ConditionsBreast Cancer

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Breast Cancer
Sponsor
Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Enrollment
300
Locations
1
Primary Endpoint
dose distribution of GTV
Status
Recruiting
Last Updated
3 years ago

Overview

Brief Summary

Radiotherapy after breast conserving therapy plays an important role in early stage breast cancer patients. It not only results in a reduction in local and regional recurrence but also decrease the death rate effectively. For adjuvant radiotherapy, supine positioning is the most common approach and has multiple advantages. Due to deformability and softness of the breast, during simulation and treatment in supine position, the breast stretches over the chest wall, especially in patients with large and pendulous glands. Thus the organs at risk (OARs) received dose increased. The radiotherapeutic toxicity are unavoidable. Some present studies show that the prone positioning of patients can improve dose homogeneity and reduce the dose distribution in OARs in patients with large and pendulous glands. Chinese women have relatively small breasts, the advantages of those have not been established. Therefore, investigators compared the parameters between supine and prone positions for whole breast irradiation after conserving surgery.

Detailed Description

Objective To investigate the difference of target volumes and dosimetric parameters between supine and prone positions for whole breast irradiation after conserving surgery. Methods Breast cancer patients with T1-2N0M0 stage who underwent radiation therapy after conserving surgery were enrolled. Supine and Prone scan sets were acquired during free breathing for all patients. Target volumes and organs at risk (OARs) including heart, ipsilateral lung and bilateral breast were contoured by the same radiation oncologist. The tumor bed (TB) was determined based on surgical clips. The Clinical target volume (CTV)consisted of the whole breast. The planning target volume (PTV) was CTV plus 0.5cm. The boost of PTV (PTVboost) was TB plus 0.5cm. Dosimetric parameters of target volumes and OARs were compared between supine and prone position.

Registry
clinicaltrials.gov
Start Date
January 1, 2019
End Date
November 1, 2023
Last Updated
3 years ago
Study Type
Interventional
Study Design
Single Group
Sex
Female

Investigators

Responsible Party
Principal Investigator
Principal Investigator

NING_LI

professor

Cancer Institute and Hospital, Chinese Academy of Medical Sciences

Eligibility Criteria

Inclusion Criteria

  • Breast cancer patients with T1-T2N0M0 stage who underwent radiation therapy after conserving surgery
  • exhibited normal arm movement aſter surgery
  • had no chronic lung diseases
  • Written informed consent forms

Exclusion Criteria

  • Breast cancer patients with radical surgery
  • could not exhibit normal arm movement after surgery
  • had chronic lung diseases
  • refused informed consent forms

Outcomes

Primary Outcomes

dose distribution of GTV

Time Frame: 1 year

the difference of GTV (Gross tumor target) between two plans

dose distribution of CTV

Time Frame: 1 year

the difference of CTV (clinical target volume) between two plans

dose distribution of ipsilateral lung

Time Frame: 1 year

the difference of ipsilateral lung dose distribution between two plans

dose distribution of heart

Time Frame: 1 year

the difference of heart dose distribution between two plans

dose distribution of bilateral breasts

Time Frame: 1 year

the difference of bilateral breasts dose distribution between two plans

dose distribution of PTV

Time Frame: 1 year

the difference of PTV (planing target volume) between two plans

Study Sites (1)

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