Do cerebral microbleeds in asymptomatic individuals reflect early CAA? The Early Detection of Angiopathy (EDAN) Study - Microbleeds and early CAA

Erasmus MC, Universitair Medisch Centrum Rotterdam0 个研究点目标入组 60 人开始时间: 待定最近更新: 2024年4月29日

适应症

试验速览

暂无简介。

•1) One or more strictly lobar CMB on previously performed 3D T2*-weighted GRE MRI
•2) Ability and willingness to provide written informed consent
•3) Age >=60. There is no upper age limit or restriction on race or gender for study participation.

•1) Other definite cause of microbleeds of hemorrhage. Exclusion causes are excessive anticoagulation (INR >3.0), antecedent head trauma or ischemic stroke, CNS tumor, vascular malformation, vasculitis, and blood dyscrasia
•2) History of symptomatic hemorrhagic stroke
•3) Microbleeds outside lobar or cerebellar brain regions (e.g. basal ganglia, thalamus, brainstem) demonstrated by neuroimaging. The presence of additional cerebellar CMBs is not an exclusion criterium, as CAA can affect the cerebellum.
•4) Dementia
•5) Contra-indication to MRI (e.g. cranial metallic implant, cardiac pacemaker, severe claustrophobia)
•6) Specific contraindications to fMRI, i.e.:
•a. History of diabetes, ischemic stroke, transient ischemic attack, carotid/intracranial artery stenosis
•b. Current tobacco use
•c. Change in antihypertensive medication within the previous three months.
•d. Seizure within prior year
•e. Noncorrectable visual impairment

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