Three-dimensional Assessment of Intraventricular Dyssynchrony Using Fast Dobutamine Gated SPECT
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 21
- 试验地点
- 1
- 主要终点
- measures of dyssynchrony parameters
研究概览
简要总结
The prognosis of patients with heart failure has improved due to recent breakthrough in medical treatment and cardiac resynchronization devices. However, there is no paraclinical parameter to assess response to cardiac resynchronization therapy (CRT). This is a major issue since about a third of implanted patients will not be improved by CRT. CZT SPECT allows to perform myocardial perfusion imaging in less than 4 minutes and is able to study myocardial perfusion, viability, left ventricular function, but also ventricular asynchrony.
Using low-dose dobutamine gated SPECT and CZT camera, we aimed to assess left ventricular dyssynchrony in viable segments in patients with heart failure eligible for CRT.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient with heart failure on optimal medical therapy and targeted for cardiac resynchronization therapy according to current recommendations;
- •Age over 18 years
- •Clinically stable (without hospitalization for heart failure in the last month)
- •Sinus rhythm
- •Social security insurance
- •Signed consent form
排除标准
- •Recent history (less than 21 days) of acute coronary syndrome or unstable angina;
- •Recent history (less than 1 month) of acute heart failure;
- •Right bundle branch block;
- •Irregular heart rate;
- •Double-chamber cardiac pacemaker
- •Patients previously implanted with a single-chamber cardioverter-defibrillator must have at least 99 percent of unstimulated QRS.
- •Countraindication to dobutamine therapy;
- •Valvular heart disease, congenital heart disease, hypertrophic cardiomyopathy;
- •Significant Ventricular arrhythmias;
- •Hypertension (upper than 160/100 mmHg);
- •Pregnant, breastfeeding or guardianship
研究组 & 干预措施
myocardial perfusion scintigraphy
Low-dose dobutamine gated SPECT and CZT camera for the assessment of parameters of left ventricular dyssynchrony in heart failure patients eligible for the implantation of a cardiac resynchronization device.
干预措施: myocardial perfusion scintigraphy (Other)
结局指标
主要结局
measures of dyssynchrony parameters
时间窗: baseline
The primary endpoint is reproducible quantitative measures of dyssynchrony parameters between two successive acquisitions basal (entropy, bandwidth, standard deviation phase histogram).
次要结局
未报告次要终点