A Proteomic Analysis for Understanding the Link Between Migraine and Cardiovascular Disease
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- Correlation between migraine and proteomic profiling of plasma
研究概览
简要总结
This is a multicenter, prospective observational study. Will be collecting data from 90 consecutive patients (aged 25- 60 years ) with and without migraine admitted at our Hospital. Primary aim of the study will be to assess the correlation between migraine and proteomic profiling of plasma and their possible correlation with known cardio and cerebrovascular disease and Cardiovascular (CV) risk factors.
详细描述
Ninety consecutive patients hospitalized for noncoronary artery disease will follow their clinical course. They will be classified into symptomatic for migraine with aura (N=45) and migraine free (N=45) and will be enrolled in the study. Patients will be screened for migraine characteristics and a comprehensive clinical analysis, including sex-related cardiovascular risk factors, will be collected. To achieve the study objective, blood will be drawn to do targeted proteomic evaluation of proteins relevant to Cardiovascular disease (CVD), inflammation, immune response, and neurological disorders, in order to compare the profile of migraine patients with that obtained in patients without migraine.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 25 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age >25 years and > 60 years
- •Signed patient informed consent form (ICF)
- •Non-coronary disease
排除标准
- •Age < 25 years and > 60 years
- •Acute myocardial infarction (MI)
- •Chronic kidney disease: glomerular filtration rate (GFR) < 30 ml/min
- •Severe mitral or aortic valvular disease
- •Acute heart failure
- •Reduced left ventricular (LV) function (Ejection Fraction < 35%)
- •Atrial Fibrillation
结局指标
主要结局
Correlation between migraine and proteomic profiling of plasma
时间窗: October 2025
A blood sample will be obtained to perform a targeted proteomic assessment of proteins relevant in CVD, inflammation, immune response and neurological disorders in order to compare migraineurs patients profile with the one obtained in migraine-free patients
次要结局
未报告次要终点