Drainage of Tuberculous Pleural Effusions
Not Applicable
Completed
- Conditions
- Tuberculous Pleurisy
- Registration Number
- NCT00524147
- Lead Sponsor
- Taipei Medical University Hospital
- Brief Summary
Tuberculous (TB) pleurisy can cause clinical symptoms and pleural fibrosis with resultant residual pleural thickening (RPT). Therapeutic thoracentesis or initial complete drainage in addition to anti-TB drugs have been tried to rapidly relieve dyspnea caused by effusion and to decrease the occurrence of RPT. However, contradictory results are reported without clear reasons. The researchers' hypothesis is that, in addition to anti-TB medications, early effective evacuation of inflammatory exudates with or without fibrinolytic agents may hasten resolution of pleural effusion, reduce the occurrence of RPT and finally improve long-term functional outcome in patients with TB pleurisy.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 64
Inclusion Criteria
- Diagnosis of tuberculous pleurisy
Exclusion Criteria
- History of invasive procedures directed into the pleural cavity
- Recent severe trauma, hemorrhage, or stroke; bleeding disorder or anticoagulant therapy
- Use of streptokinase in the previous 2 years
- Lack of clinical symptoms caused by effusions
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Chest radiography, daily monitoring of the volume of fluid drained, the time needed for resolution of fever and dyspnea, and total amounts of fluid drained, and the length of chest drainage and hospitalization baseline, daily after treatment within admission
- Secondary Outcome Measures
Name Time Method Chest radiography and pulmonary function testing with spirometry At discharge and at 2, 4, 6, and 12 months
Trial Locations
- Locations (1)
Taipei Medical University Hospital
🇨🇳Taipei, Taiwan