CTRI/2024/03/064845
Not yet recruiting
未知
Vitamin-D level in sepsis and its outcome in patients admitted in medical intensive care unit - NI
Research and development department, Datta Meghe institute of higher education and research0 sites0 target enrollmentTBD
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- Not specified
- Sponsor
- Research and development department, Datta Meghe institute of higher education and research
- Status
- Not yet recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •After written inform consent all the patients of more than 18 years of age who will be screened clinically for sepsis and low vitamin D levels, relevant biochemical analysis will be done and they will be considered for study if they met the accepted definition for sepsis:
- •1\) confirmed or suspected source of infection determined by the treating clinician and/or a serum lactate level .2\.5 mmol/L1\.
- •2\) Two or more criteria for the systemic inflammatory response syndrome (SIRS), defined as:
- •a) Temperature greater than 38C or less than 36C1\.
- •b) Respiratory rate greater than 20 breaths per minute or partial pressure of carbon dioxide less than 32 mm Hg1\.
- •c) Heart rate greater than 90 beats per minute1\.
- •d) White blood cell count greater than 12,000 or less than 4,000 cells per mm3, or greater than 10% immature forms1
- •3\) Presence of hypotension (mean arterial pressure,70 mm Hg or systolic blood pressure,90 mm Hg) despite adequate fluid resuscitation or requiring vasopressor therapy1\.
- •In the inclusion criteria, patients will be further divided into classes according to the values of Vitamin D:
- •Reference level : 30ng/ml.
Exclusion Criteria
- •Exclusion criteria1
- •1\)Pregnant and lactating mothers.
- •2\)Post cardiopulmonary resuscitated patient.
- •3\)Patient taking multivitamin, or food supplements which contain Vitamin D.
- •4\)Patient with malabsorption syndromes.
- •5\)Patients with chronic diarrhea.
- •6\)Patients not willing to give informed consent
Outcomes
Primary Outcomes
Not specified
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