Biomarkers of Chronic Obstructive Pulmonary Disease

Completed

• Conditions: COPD; Asthma-COPD Overlap Syndrome; Asthma
• Interventions: Other: Physical examinations; Diagnostic Test: blood test

• Registration Number: NCT04963023
• Lead Sponsor: Centre Hospitalier Universitaire, Amiens

Brief Summary

There are few studies about immunological explorations in COPD. Because of the complications of lung biopsies, analyses are generally made on blood samples instead of lung tissue. No study tried to classify COPD vs Asthma vs ACOS. The investigators wondered if there were differences in biomarkers between these groups. The investigators decided to open a pilot-study among COPD patients followed in Amiens-University Hospital. Each patient will be examined and a blood-test will be performed.

Detailed Description

Not available

Study Timeline

• Study Start: 2021-06-15
• Study First Submitted: 2021-06-17
• Study First Submitted QC: 2021-07-05
• Study First Posted: 2021-07-15
• Primary Completion: 2023-07-01
• Study Completion: 2023-07-01
• Status Verified: 2023-08
• Last Update Submitted: 2023-08-22
• Last Update Posted: 2023-08-23

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 75

Inclusion Criteria

• BPCO patients
• ACOS patients
• asthmatic patient without BPCO

Exclusion Criteria

• infection
• exacerbation
• immunosuppressive treatment
• immunosuppressive disease

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
frequent exacerbation patients	Physical examinations	-
Asthmatic patients (without COPD)	blood test	-
frequent exacerbation patients	blood test	-
non frequent exacerbation patients	blood test	-
Asthma-and-COPD overlap syndrome	Physical examinations	-
non frequent exacerbation patients	Physical examinations	-
Asthma-and-COPD overlap syndrome	blood test	-
Asthmatic patients (without COPD)	Physical examinations	-

Primary Outcome Measures

Name	Time	Method
identification specific blood immunologic marker for COPD	one hour	COPD biomarkers are blood immunologic markers

Secondary Outcome Measures

Name	Time	Method
c-reactive protein concentration variation between COPD and asthmatic patients	one hour
Complete blood count (CBC) Variation between COPD and asthmatic patients	one hour
Plasma protein electrophoresis profile Variation between COPD and asthmatic patients	one hour

Trial Locations

Locations (1)

CHU Amiens; 🇫🇷 Amiens, France